Disease on EC 2.3.2.34 - E2 NEDD8-conjugating enzyme
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Atherosclerosis
Identification of candidate targets for the diagnosis and treatment of atherosclerosis by bioinformatics analysis.
Carcinoma
Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma.
Carcinoma
Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M.
Carcinoma
NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma.
Carcinoma, Hepatocellular
UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis.
Carcinoma, Hepatocellular
UBE2M promotes cell proliferation via the ?-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Carcinoma, Squamous Cell
Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M.
Cholangiocarcinoma
Knockdown of Nedd8?conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells.
Colorectal Neoplasms
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
Endometrial Neoplasms
MLN4924 inhibits cell proliferation by targeting the activated neddylation pathway in endometrial carcinoma.
Esophageal Squamous Cell Carcinoma
NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma.
Hypersensitivity
Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.
Infections
RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response.
Infections
Treatment of Yersinia similis with the cationic lipid DOTAP enhances adhesion to and invasion into intestinal epithelial cells - A proof-of-principle study.
Kidney Neoplasms
A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification.
Lung Neoplasms
Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity.
Lung Neoplasms
Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage.
Lung Neoplasms
UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F.
Lung Neoplasms
Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer.
Lymphatic Metastasis
UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis.
Neoplasms
Correlation of histopathologic characteristics to protein expression and function in malignant melanoma.
Neoplasms
Knockdown of Nedd8?conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells.
Neoplasms
MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma.
Neoplasms
Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage.
Neoplasms
Negative Regulation of NEDD8 Conjugation Pathway by Novel Molecules and Agents for Anticancer Therapy.
Neoplasms
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
Neoplasms
Suppression of glioblastoma by targeting the overactivated protein neddylation pathway.
Neoplasms
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
Neoplasms
UBE2M promotes cell proliferation via the ?-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Pancreatitis
Neddylation pathway alleviates chronic pancreatitis by reducing HIF1?-CCL5-dependent macrophage infiltration.
Prostatic Neoplasms
Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation.
Prostatic Neoplasms
Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy.
Prostatic Neoplasms
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
ring-type e3 ubiquitin transferase deficiency
RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response.
Squamous Cell Carcinoma of Head and Neck
The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma.
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