Disease on EC 2.1.1.204 - tRNA (cytosine38-C5)-methyltransferase
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Adenocarcinoma of Lung
RNA methyltransferase METTL3 induces intrinsic resistance to gefitinib by combining with MET to regulate PI3K/AKT pathway in lung adenocarcinoma.
Bone Resorption
Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation.
Breast Neoplasms
BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells.
Breast Neoplasms
Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer.
Carcinoma
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
Carcinoma, Ehrlich Tumor
Recognition of the ribosomal RNA structures by purified nucleolar RNA methyltransferase.
Carcinoma, Hepatocellular
RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy-related-1 in vitro and in vivo.
Carcinoma, Hepatocellular
The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene.
Carcinoma, Hepatocellular
The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives.
Carcinoma, Hepatocellular
[METTL14 as a predictor of postoperative survival outcomes of patients with hepatocellular carcinoma].
Carcinoma, Non-Small-Cell Lung
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer.
Cystic Fibrosis
Identification of Aminoglycoside-resistant Pseudomonas aeruginosa producing RmtG 16S ribosomal RNA methyltransferase in a cystic fibrosis patient.
Gastrointestinal Neoplasms
Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer.
Glioma
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program.
Hearing Loss
Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness.
Infections
Temperature-dependent survival of Turnip crinkle virus-infected arabidopsis plants relies on an RNA silencing-based defense that requires dcl2, AGO2, and HEN1.
Intellectual Disability
Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability.
Neoplasm Metastasis
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Neoplasms
METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma.
Neoplasms
METTL3?mediated m6A modification of Bcl?2 mRNA promotes non?small cell lung cancer progression.
Neoplasms
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Neoplasms
Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer.
Neoplasms
Recognition of the ribosomal RNA structures by purified nucleolar RNA methyltransferase.
Neoplasms
Regulation of telomere homeostasis and genomic stability in cancer by N 6-adenosine methylation (m6A).
Neoplasms
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.
Neoplasms
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
Neoplasms
The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.
Neoplasms
Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response.
Neoplasms
Virion-associated and cellular RNA methylase activity in normal and neoplastic mammary tissue from mammary tumor virus-infected and -uninfected mice.
Osteoarthritis
METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte.
Pancreatic Neoplasms
The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation.
Spinal Dysraphism
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Squamous Cell Carcinoma of Head and Neck
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
Stomach Neoplasms
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.
Tuberculosis
A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis.
Wilms Tumor
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.
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