Reference on EC 1.14.19.22 - acyl-lipid omega-6 desaturase (cytochrome b5)
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Slack, C.R.; Roughan, P.G.; Terpstra, J.
Some properties of a microsomal oleate desaturase from leaves
Biochem. J.
155
71-80
1976
Pisum sativum
Demandre, C.; Vigh, L.; Justin, A.M.; Jolliot, A.; Wolf, C.; Mazliak, P.
Effects of the catalytic hydrogenation of microsomal lipids upon four enzyme activities involved in oleic acid desaturation
Plant Sci.
44
13-21
1986
Solanum tuberosum
-
Stymne, S.; Appelqvist, L.A.
The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in microsomes of developing safflower seeds
Eur. J. Biochem.
90
223-229
1978
Carthamus tinctorius
Umeki, S.; Nozawa, Y.
Thermoadaptive regulation of microsomal desaturase and electron-transport enzyme activities in lipid-manipulated Tetrahymena cells. Extent of unsaturated fatty acid production is dependent on membrane fluidity before temperature down-shift
Biochim. Biophys. Acta
793
123-128
1984
Tetrahymena pyriformis, Tetrahymena pyriformis NT-1
Cheesbrough, T.M.
Changes in the enzymes for fatty acid synthesis and desaturation during acclimation of developing soybean seeds to altered growth temperature
Plant Physiol.
90
760-764
1989
Glycine max
Murphy, D.J.; Woodrow, I.E.; Latzko, E.; Mukherjee, K.D.
Solubilisation of oleoyl-CoA thioesteras, oleoyl-CoA:phosphatidylcholine acyltransferase and oleoyl phosphatidylcholine desaturase
FEBS Lett.
162
442-446
1983
Pisum sativum
-
Citharel, B.; Oursel, A.; Mazliak, P.
Desaturation of oleoyl and linoleoyl residues linked to phospholipids in growing roots of yellow lupin
FEBS Lett.
161
251-256
1983
Lupinus luteus
-
Murphy, D.J.; Woodrow, I.E.; Mukherjee, K.D.
Substrate specificities of the enzymes of the oleate desaturase system from photosynthetic tissue
Biochem. J.
225
267-270
1985
Pisum sativum
Browse, J.; Slack, C.R.
The effects of temperature and oxygen on the rates of fatty acid synthesis and oleate desaturation in seaflower (Carthamus tinctorius) seed
Biochim. Biophys. Acta
753
145-152
1983
Carthamus tinctorius
-
Wilson, A.C.; Adams, W.C.; Miller, R.W.
Lipid involvement in oleoyl CoA desaturase activity of Fusarium oxysporum microsomes
Can. J. Biochem.
58
97-102
1980
Fusarium oxysporum
Murphy, D.J.; Mukherjee, K.D.; Latzko, E.
Lipid metabolism in microsomal fraction from photosynthetic tissue. Effects of catalase and hydrogen peroxide on oleate desaturation
Biochem. J.
213
249-252
1983
Pisum sativum
Hawke, J.C.; Stumpf, P.K.
Desaturation of oleic and linoleic acids by leaves of dark- and light-grown maize seedlings
Plant Physiol.
65
1027-1030
1980
Zea mays
Slack, C.R.; Grattan Roughan, P.; Browse, J.
Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations from cotyledons of safflower (Carthamus tinctorius) seed
Biochem. J.
179
649-656
1979
Carthamus tinctorius, Carthamus tinctorius cultivar 0-22
Pugh, E.L.; Kates, M.
Characterization of a membrane-bound phospholipid desaturase system of candida lipolytica
Biochim. Biophys. Acta
380
442-453
1975
Yarrowia lipolytica
Sarmiento, C.; Garces, R.; Mancha, M.
Oleate desaturation and acyl turnover in sunflower (Helianthus annuus L.) seed lipids during rapid temperature adaption
Planta
205
595-600
1998
Helianthus annuus
-
Gray, D.A.; Kekwick, R.G.O.
Intracellular location of oleate desaturase and associated constituents in developing sunflower (Helianthus annuus) seeds
Plant Sci.
119
11-21
1996
Helianthus annuus
-
Gray, D.A.; Kekwick, R.G.O.
Oleate desaturase activity in sunflower (Helianthus annuus) seeds and its relation to associated constituents during seed development
Plant Sci.
115
39-47
1996
Helianthus annuus
-
Garcia-Diaz, M.T.; Martinez-Rivas, J.M.; Mancha, M.
Temperature and oxygen regulation of oleate desaturation in developing sunflower (Helianthus annuus) seeds
Physiol. Plant.
114
13-20
2002
Helianthus annuus
Petrini, G.A.; Altabe, S.G.; Uttaro, A.D.
Trypanosoma brucei oleate desaturase may use a cytochrome b5-like domain in another desaturase as an electron donor
Eur. J. Biochem.
271
1079-1086
2004
Trypanosoma brucei (Q6UCJ6), Trypanosoma brucei
Esteban, A.B.; Sicardo, M.D.; Mancha, M.; Martinez-Rivas, J.M.
Growth temperature control of the linoleic acid content in safflower (Carthamus tinctorius) seed oil
J. Agric. Food Chem.
52
332-336
2004
Carthamus tinctorius
Broadwater, J.A.; Whittle, E.; Shanklin, J.
Desaturation and hydroxylation. Residues 148 and 324 of Arabidopsis FAD2, in addition to substrate chain length, exert a major influence in partitioning of catalytic specificity
J. Biol. Chem.
277
15613-15620
2002
Arabidopsis thaliana
Wilson, R.A.; Calvo, A.M.; Chang, P.K.; Keller, N.P.
Characterization of the Aspergillus parasiticus DELTA12-desaturase gene: A role for lipid metabolism in the Aspergillus-seed interaction
Microbiology
150
2881-2888
2004
Aspergillus parasiticus
Martinez-Rivas, J.M.; Sanchez-Garcia, A.; Sicardo, M.D.; Garcia-Diaz, M.T.; Mancha, M.
Oxygen-independent temperature regulation of the microsomal oleate desaturase (FAD2) activity in developing sunflower (Helianthus annuus) seeds
Physiol. Plant.
117
179-185
2003
Helianthus annuus
-
Maldonado, R.A.; Kuniyoshi, R.K.; Linss, J.G.; Almeida, I.C.
Trypanosoma cruzi oleate desaturase: molecular characterization and comparative analysis in other trypanosomatids
J. Parasitol.
92
1064-1074
2006
Trypanosoma cruzi
Li, L.; Wang, X.; Gai, J.; Yu, D.
Molecular cloning and characterization of a novel microsomal oleate desaturase gene from soybean
J. Plant Physiol.
164
1516-1526
2007
Glycine max (Q19AK7), Glycine max
Schuppert, G.F.; Tang, S.; Slabaugh, M.B.; Knapp, S.J.
The sunflower high-oleic mutant Ol carries variable tandem repeats of FAD2-1, a seed-specific oleoyl-phosphatidyl choline desaturase
Mol. Breed.
17
241-256
2006
Helianthus annuus
Kim, M.J.; Kim, H.; Shin, J.S.; Chung, C.H.; Ohlrogge, J.B.; Suh, M.C.
Seed-specific expression of sesame microsomal oleic acid desaturase is controlled by combinatorial properties between negative cis-regulatory elements in the SeFAD2 promoter and enhancers in the 5-UTR intron
Mol. Genet. Genomics
276
351-368
2006
Sesamum indicum
Banilas, G.; Moressis, A.; Nikoloudakis, N.; Hatzopoulos, P.
Spatial and temporal expressions of two distinct oleate desaturases from olive (Olea europaea L.)
Plant Sci.
168
547-555
2005
Olea europaea (Q8GVC9)
Reza, M.A.; Goldenkova-Pavlova, I.V.; Pchelkin, V.P.; Tsydendambaev, V.D.; Los, D.A.; Nosov, A.M.
Acyl-lipid DELTA12-desaturase of the cyanobacterium increases the unsaturation degree in transgenic potato (Solanum tuberosum L.)
Biologia
53
4-7
2007
Synechocystis sp.
-
Chu, Y.; Ramos, L.; Holbrook, C.C.; Ozias-Akins, P.
Frequency of a loss-of-function mutation in oleoyl-PC desaturase (ahFAD2A) in the mini-core of the U.S. peanut germplasm collection
Crop Sci.
47
2372-2378
2007
Arachis hypogaea
-
Li, L.; Wang, X.; Gai, J.; Yu, D.
Isolation and characterization of a seed-specific isoform of microsomal omega-6 fatty acid desaturase gene (FAD2-1B) from soybean
DNA Seq.
19
28-36
2008
Glycine max (Q19AK8), Glycine max
Rolletschek, H.; Borisjuk, L.; Sanchez-Garcia, A.; Gotor, C.; Romero, L.C.; Martinez-Rivas, J.M.; Mancha, M.
Temperature-dependent endogenous oxygen concentration regulates microsomal oleate desaturase in developing sunflower seeds
J. Exp. Bot.
58
3171-3181
2007
Helianthus annuus
Kargiotidou, A.; Deli, D.; Galanopoulou, D.; Tsaftaris, A.; Farmaki, T.
Low temperature and light regulate delta 12 fatty acid desaturases (FAD2) at a transcriptional level in cotton (Gossypium hirsutum)
J. Exp. Bot.
59
2043-2056
2008
Gossypium hirsutum (Q8W2B9), Gossypium hirsutum
Hernandez, M.L.; Padilla, M.N.; Mancha, M.; Martinez-Rivas, J.M.
Expression analysis identifies FAD2-2 as the olive oleate desaturase gene mainly responsible for the linoleic acid content in virgin olive oil
J. Agric. Food Chem.
57
6199-6206
2009
Olea europaea (A9UKE1), Olea europaea (Q4QWZ0), Olea europaea (Q4QWZ1)
Lacombe, S.; Souyris, I.; Berville, A.J.
An insertion of oleate desaturase homologous sequence silences via siRNA the functional gene leading to high oleic acid content in sunflower seed oil
Mol. Genet. Genomics
281
43-54
2009
Helianthus annuus (O24499)
Dierking, E.C.; Bilyeu, K.D.
New sources of soybean seed meal and oil composition traits identified through TILLING
BMC Plant Biol.
9
89
2009
Glycine max
Amiri, R.M.; Yureva, N.O.; Shimshilashvili, K.R.; Goldenkova-Pavlova, I.V.; Pchelkin, V.P.; Kuznitsova, E.I.; Tsydendambaev, V.D.; Trunova, T.I.; Los, D.A.; Jouzani, G.S.; Nosov, A.M.
Expression of acyl-lipid Delta12-desaturase gene in prokaryotic and eukaryotic cells and its effect on cold stress tolerance of potato
J. Integr. Plant Biol.
52
289-297
2010
Synechocystis sp.
Song, W.; Maeda, H.; DellaPenna, D.
Mutations of the ER to plastid lipid transporters TGD1, 2, 3 and 4 and the ER oleate desaturase FAD2 suppress the low temperature-induced phenotype of Arabidopsis tocopherol-deficient mutant vte2
Plant J.
62
1004-1018
2010
Arabidopsis thaliana
Lei, N.; Peng, S.; Niu, B.; Chen, J.; Zhou, J.; Tang, L.; Xu, Y.; Wang, S.; Chen, F.
Molecular cloning and characterization of a novel microsomal oleate desaturase gene DiFAD2 from Davidia involucrata Baill
Biol. Plant.
54
41-46
2010
Davidia involucrata
-
Pham, A.T.; Lee, J.D.; Shannon, J.G.; Bilyeu, K.D.
Mutant alleles of FAD2-1A and FAD2-1B combine to produce soybeans with the high oleic acid seed oil trait
BMC Plant Biol.
10
195
2010
Glycine max
Yan, Z.; Zhuo, L.; Mulan, J.; Xia, W.; Yangmin, G.; Yinbo, Z.; Fenghong, H.
Clone and identification of bifunctional DELTA12/DELTA15 fatty acid desaturase LKFAD15 from Lipomyces kononenkoae
Food Sci. Biotechnol.
22
573-576
2013
Lipomyces kononenkoae (H9CP21)
-
Matsuda, T.; Sakaguchi, K.; Kobayashi, T.; Abe, E.; Kurano, N.; Sato, A.; Okita, Y.; Sugimoto, S.; Hama, Y.; Hayashi, M.; Okino, N.; Ito, M.
Molecular cloning of a Pinguiochrysis pyriformis oleate-specific microsomal DELTA12-fatty acid desaturase and functional analysis in yeasts and thraustochytrids
J. Biochem.
150
375-383
2011
Pinguiochrysis pyriformis
Zhou, X.; Green, A.; Singh, S.
Caenorhabditis elegans ?12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the DELTA12 and DELTA15 positions
J. Biol. Chem.
286
43644-43650
2011
Caenorhabditis elegans
Matsuda, T.; Sakaguchi, K.; Hamaguchi, R.; Kobayashi, T.; Abe, E.; Hama, Y.; Hayashi, M.; Honda, D.; Okita, Y.; Sugimoto, S.; Okino, N.; Ito, M.
Analysis of DELTA12-fatty acid desaturase function revealed that two distinct pathways are active for the synthesis of PUFAs in T. aureum ATCC 34304
J. Lipid Res.
53
1210-1222
2012
Thraustochytrium aureum, Thraustochytrium aureum ATCC 3404
Shi, J.; Cao, Y.; Fan, X.; Li, M.; Wang, Y.; Ming, F.
A rice microsomal delta-12 fatty acid desaturase can enhance resistance to cold stress in yeast and Oryza sativa
Mol. Breed.
29
743-757
2012
Oryza sativa
-
Jung, J.H.; Kim, H.; Go, Y.S.; Lee, S.B.; Hur, C.G.; Kim, H.U.; Suh, M.C.
Identification of functional BrFAD2-1 gene encoding microsomal delta-12 fatty acid desaturase from Brassica rapa and development of Brassica napus containing high oleic acid contents
Plant Cell Rep.
30
1881-1892
2011
Brassica rapa
Guan, L.; Xu, Y.; Wang, Y.; Chen, L.; Shao, J.; Wu, W.
Isolation and characterization of a temperature-regulated microsomal oleate desaturase gene (CtFAD2-1) from Safflower (Carthamus tinctorius L.)
Plant Mol. Biol. Rep.
30
391-402
2012
Carthamus tinctorius
-
Kang, J.; Snapp, A.R.; Lu, C.
Identification of three genes encoding microsomal oleate desaturases (FAD2) from the oilseed crop Camelina sativa
Plant Physiol. Biochem.
49
223-229
2011
Camelina sativa
Kearns, E.V.; Hugly, S.; Somerville, C.R.
The role of cytochrome b5 in DELTA12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.)
Arch. Biochem. Biophys.
284
431-436
1991
Carthamus tinctorius
Smith, M.A.; Cross, A.R.; Jones, O.T.; Griffiths, W.T.; Stymne, S.; Stobart, K.
Electron-transport components of the 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTA 12-desaturase (DELTA12-desaturase) in microsomal preparations from developing safflower (Carthamus tinctorius L.) cotyledons
Biochem. J.
272
23-29
1990
Carthamus tinctorius, Carthamus tinctorius var High Linoleate
Smith, M.A.; Jonsson, L.; Stymne, S.; Stobart, K.
Evidence for cytochrome b5 as an electron donor in ricinoleic acid biosynthesis in microsomal preparations from developing castor bean (Ricinus communis L.)
Biochem. J.
287
141-144
1992
Ricinus communis
Sperling, P.; Schmidt, H.; Heinz, E.
A cytochrome-b5-containing fusion protein similar to plant acyl lipid desaturases
Eur. J. Biochem.
232
798-805
1995
Helianthus annuus
Miquel, M.; Browse, J.
Arabidopsis mutants deficient in polyunsaturated fatty acid synthesis. Biochemical and genetic characterization of a plant oleoyl-phosphatidylcholine desaturase
J. Biol. Chem.
267
1502-1509
1992
Arabidopsis thaliana
Caiveau, O.; Fortune, D.; Cantrel, C.; Zachowski, A.; Moreau, F.
Consequences of omega-6-oleate desaturase deficiency on lipid dynamics and functional properties of mitochondrial membranes of Arabidopsis thaliana
J. Biol. Chem.
276
5788-5794
2001
Arabidopsis thaliana (P46313), Arabidopsis thaliana
Yang, M.; Xu, Y.
Oleate accumulation, induced by silencing of microsomal omega-6 desaturase, declines with leaf expansion in transgenic tobacco
J. Plant Physiol.
164
23-30
2007
Nicotiana tabacum (Q6DMQ8), Nicotiana tabacum
Okuley, J.; Lightner, J.; Feldmann, K.; Yadav, N.; Lark, E.; Browse, J.
Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis
Plant Cell
6
147-158
1994
Arabidopsis thaliana (P46313)
Kumar, R.; Tran, L.S.; Neelakandan, A.K.; Nguyen, H.T.
Higher plant cytochrome b5 polypeptides modulate fatty acid desaturation
PLoS ONE
7
e31370
2012
Arabidopsis thaliana (P46313), Glycine max
Dehghan Nayeri, F.; Yarizade, K.
Bioinformatics study of delta-12 fatty acid desaturase 2 (FAD2) gene in oilseeds
Mol. Biol. Rep.
41
5077-5087
2014
Linum usitatissimum (B7ST72), Arachis hypogaea (E1A444), Linum grandiflorum (G4Y082), Helianthus annuus (Q8W2F0), Sesamum indicum (Q9LLL7), Vernonia galamensis (Q9SP28)
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