2.4.1.129: peptidoglycan glycosyltransferase

This is an abbreviated version!
For detailed information about peptidoglycan glycosyltransferase, go to the full flat file.

Reaction

Synonyms

bacterial cell wall glycosyltransferase, bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase, bifunctional penicillin-binding protein, class A penicillin-binding protein, class B penicillin-binding protein, DD-transpeptidase, ftsI, glycosyltransferase, peptidoglycan, glycosyltransferase/acyltransferase penicillin-binding protein 4, GTase, MGT, monofunctional glycosyltransferase, mrcB, MtgA, murein synthase, PBP, PBP 1a, PBP 2b, PBP 2x, PBP 3, PBP-1A, PBP-1B, PBP-1C, PBP-2, PBP1, PBP1a, PBP1b, PBP1c, PBP2, PBP2A, PBP2b, PBP2c, PBP2d, PBP3, PBP4, PBP7, PBP8, PBPA, PenA, penicillin binding protein, penicillin binding protein 1b, penicillin-binding protein, penicillin-binding protein 1a, penicillin-binding protein 1B, penicillin-binding protein 2, penicillin-binding protein 3, peptidoglycan glycosyltransferase, peptidoglycan transglycosylase, PG-II, PGT, SgtB, SpoIID

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.129 peptidoglycan glycosyltransferase

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Results	in table
15	Activating Compound
124289	AA Sequence
7	Application
1	CAS Registry Number
20	Cloned(Commentary)
7	Crystallization (Commentary)
52	General Information
52	IC50 Value
230	Inhibitors
10	kcat/KM [mM/s]
17	KM Value [mM]
34	Localization
14	Metals/Ions
5	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
96	Organism
9	Pathway
68	PDB ID
9	pH Optimum
1	pH Range
1	pI Value
67	Protein Variants
21	Purification (Commentary)
1	Reaction
1	Reaction Type
71	Reference
1	Storage Stability
93	Substrates and Products (Substrate)
8	Subunits
172	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
15	Turnover Number [1/s]

Synonyms

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Synonyms on EC 2.4.1.129 - peptidoglycan glycosyltransferase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

bacterial cell wall glycosyltransferase

2 entries

bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase

-

-

-

-

bifunctional penicillin-binding protein

3 entries

class A penicillin-binding protein

4 entries

class B penicillin-binding protein

2 entries

DD-transpeptidase

Escherichia coli

P02919

-

759728

ftsI

Pseudomonas aeruginosa

G3XD46

-

723697

glycosyltransferase, peptidoglycan

-

-

-

-

glycosyltransferase/acyltransferase penicillin-binding protein 4

Listeria monocytogenes

-

-

674265

GTase

2 entries

MGT

5 entries

monofunctional glycosyltransferase

3 entries

mrcB

Escherichia coli

P02919

-

758901

MtgA

2 entries

murein synthase

Escherichia coli

P02919

-

706545

PBP

3 entries

PBP 1a

Streptococcus pneumoniae

Q4TUQ8

isoform

701726

PBP 2b

Streptococcus pneumoniae

P0A3M5

isoform

701726

PBP 2x

Streptococcus pneumoniae

P14677

isoform

701726

PBP 3

2 entries

PBP-1A

Brucella melitensis

-

isoform

706885

PBP-1B

2 entries

PBP-1C

Brucella melitensis

-

isoform

706885

PBP-2

Brucella melitensis

-

isoform

706885

PBP1

Bacillus subtilis

-

isoform

703349

PBP1a

11 entries

PBP1b

7 entries

PBP1c

4 entries

PBP2

8 entries

PBP2A

5 entries

PBP2b

3 entries

PBP2c

Bacillus subtilis

-

isoform

703349

PBP2d

Bacillus subtilis

-

isoform

703349

PBP3

3 entries

PBP4

2 entries

PBP7

Escherichia coli

-

isoform

703349

PBP8

Escherichia coli

-

isoform

703349

PBPA

Mycobacterium tuberculosis

-

isoform

703349

PenA

2 entries

penicillin binding protein

Staphylococcus aureus

W8U4T4

-

759431

penicillin binding protein 1b

Escherichia coli

-

-

657556

penicillin-binding protein

6 entries

penicillin-binding protein 1a

2 entries

penicillin-binding protein 1B

5 entries

penicillin-binding protein 2

5 entries

penicillin-binding protein 3

4 entries

peptidoglycan glycosyltransferase

Staphylococcus aureus

-

-

758865

peptidoglycan transglycosylase

5 entries

PG-II

-

-

-

-

PGT

8 entries

SgtB

2 entries

SpoIID

Bacillus subtilis

-

-

722336

bacterial cell wall glycosyltransferase

Escherichia coli

-

-

735922

bacterial cell wall glycosyltransferase

Staphylococcus aureus

-

-

735922

bifunctional penicillin-binding protein

Escherichia coli

-

-

735922

bifunctional penicillin-binding protein

Staphylococcus aureus

-

-

735922

bifunctional penicillin-binding protein

Staphylococcus aureus ATCC 29213

-

-

-

class A penicillin-binding protein

Escherichia coli

-

-

701718

class A penicillin-binding protein

Escherichia coli BAS849

-

-

-

class A penicillin-binding protein

Streptococcus pneumoniae

A0A0H2URT5

-

759785

class A penicillin-binding protein

Streptococcus pneumoniae ATCC BAA-334

A0A0H2URT5

-

-

class B penicillin-binding protein

Streptococcus pneumoniae

P0A3M5

-

759785

class B penicillin-binding protein

Streptococcus pneumoniae ATCC BAA-334

P0A3M5

-

-

GTase

Escherichia coli

P02919

-

759728

GTase

Staphylococcus aureus

-

-

758865

MGT

Escherichia coli

-

-

701718

MGT

Escherichia coli BAS849

-

-

-

MGT

Staphylococcus aureus

-

-

735922

MGT

Staphylococcus aureus

W8U4T4

-

759431

MGT

Staphylococcus aureus ATCC 29213

-

-

-

monofunctional glycosyltransferase

Escherichia coli

-

-

735922

monofunctional glycosyltransferase

Staphylococcus aureus

-

-

735922

monofunctional glycosyltransferase

Staphylococcus aureus ATCC 29213

-

-

-

MtgA

Escherichia coli

-

-

704276

MtgA

Staphylococcus aureus

-

-

735646, 758865

PBP

Escherichia coli

-

-

657556

PBP

Escherichia coli

P02919

-

759728

PBP

Staphylococcus aureus

W8U4T4

-

759431

PBP 3

Neisseria gonorrhoeae

O85665

-

657973

PBP 3

Pseudomonas aeruginosa

G3XD46

-

723697

PBP-1B

Brucella melitensis

-

isoform

706885

PBP-1B

Escherichia coli

P02919

-

758901

PBP1a

Aquifex aeolicus

-

-

676895, 703349, 704207

PBP1a

Aquifex aeolicus

-

isoform

701718

PBP1a

Aquifex aeolicus

O66874

-

701437

PBP1a

Caulobacter vibrioides

-

isoform

703349

PBP1a

Escherichia coli

-

-

674207, 735922

PBP1a

Escherichia coli

-

isoform

701718, 703349, 704163, 704276

PBP1a

Escherichia coli

-

the enzyme has both transglycosylase and transpeptidase activity

671367

PBP1a

Escherichia coli BAS849

-

isoform

-

PBP1a

Escherichia coli imp

-

-

-

PBP1a

Helicobacter pylori

-

isoform

701718

PBP1a

Thermotoga maritima

Q9WZY8

-

672385

PBP1b

-

-

-

-

PBP1b

Escherichia coli

-

-

658031, 658267, 659032, 659500, 674207, 704438, 735922

PBP1b

Escherichia coli

-

isoform

701718, 703349, 704163, 704276

PBP1b

Escherichia coli

-

the enzyme has both transglycosylase and transpeptidase activity

671367

PBP1b

Escherichia coli

P02919

-

706545, 736947, 758901, 759728

PBP1b

Escherichia coli BAS849

-

isoform

-

PBP1b

Escherichia coli imp

-

-

-

PBP1c

Escherichia coli

-

-

735922

PBP1c

Escherichia coli

-

isoform

701718

PBP1c

Escherichia coli BAS849

-

isoform

-

PBP1c

Escherichia coli imp

-

-

-

PBP2

Bacillus subtilis

-

-

735921

PBP2

Caulobacter vibrioides

-

isoform

703349

PBP2

Cereibacter sphaeroides

-

isoform

703349

PBP2

Escherichia coli

-

isoform

703349

PBP2

Staphylococcus aureus

-

-

701718, 703349, 705123, 735921

PBP2

Staphylococcus aureus

-

isoform

704163

PBP2

Staphylococcus aureus ATCC 29213

-

-

-

PBP2

Staphylococcus aureus NCTC 8325

-

-

-

PBP2A

Bacillus subtilis

-

isoform

703349

PBP2A

Caulobacter vibrioides

-

isoform

703349

PBP2A

Enterococcus faecalis

-

isoform

704163

PBP2A

Streptococcus pneumoniae

A0A0H2URT5

-

759785

PBP2A

Streptococcus pneumoniae ATCC BAA-334

A0A0H2URT5

-

-

PBP2b

Caulobacter vibrioides

-

isoform

703349

PBP2b

Streptococcus pneumoniae

P0A3M5

-

759785

PBP2b

Streptococcus pneumoniae ATCC BAA-334

P0A3M5

-

-

PBP3

Bacillus subtilis

-

isoform

703349

PBP3

Escherichia coli

-

isoform

703349, 704276

PBP3

Haemophilus influenzae

-

-

703388

PBP4

Bacillus subtilis

-

isoform

703349

PBP4

Listeria monocytogenes

-

-

674265

PenA

Streptococcus pneumoniae

P0A3M5

-

759785

PenA

Streptococcus pneumoniae ATCC BAA-334

P0A3M5

-

-

penicillin-binding protein

Brucella melitensis

-

-

706885

penicillin-binding protein

Enterococcus faecalis

-

-

701718, 704163

penicillin-binding protein

Escherichia coli

-

-

704163, 704276

penicillin-binding protein

Escherichia coli

P02919

-

759728

penicillin-binding protein

Staphylococcus aureus

-

-

701718, 704163

penicillin-binding protein

Streptococcus pneumoniae

P0A3M5, Q4TUQ8

-

701726

penicillin-binding protein 1a

Escherichia coli

-

the enzyme has both transglycosylase and transpeptidase activity

671367

penicillin-binding protein 1a

Thermotoga maritima

Q9WZY8

-

672385

penicillin-binding protein 1B

-

-

-

-

penicillin-binding protein 1B

Escherichia coli

-

-

658267, 659032, 659960, 672145, 704438

penicillin-binding protein 1B

Escherichia coli

-

the enzyme has both transglycosylase and transpeptidase activity

671367

penicillin-binding protein 1B

Escherichia coli

P02919

-

736947, 758901

penicillin-binding protein 1B

Escherichia coli

P02919

bifunctional transglycosylase

706545

penicillin-binding protein 2

Bacillus subtilis

-

-

735921

penicillin-binding protein 2

Staphylococcus aureus

-

-

735921

penicillin-binding protein 2

Staphylococcus aureus

-

bifunctional peptidoglycan glycosyltransferase/transpeptidase

705123

penicillin-binding protein 2

Staphylococcus aureus ATCC 29213

-

-

-

penicillin-binding protein 2

Staphylococcus aureus NCTC 8325

-

bifunctional peptidoglycan glycosyltransferase/transpeptidase

-

penicillin-binding protein 3

-

-

-

-

penicillin-binding protein 3

Haemophilus influenzae

-

-

703388

penicillin-binding protein 3

Neisseria gonorrhoeae

O85665

-

657973

penicillin-binding protein 3

Pseudomonas aeruginosa

G3XD46

-

723697

peptidoglycan transglycosylase

-

-

-

-

peptidoglycan transglycosylase

Escherichia coli

-

-

735922

peptidoglycan transglycosylase

Escherichia coli imp

-

-

-

peptidoglycan transglycosylase

Staphylococcus aureus

-

-

735922

peptidoglycan transglycosylase

Staphylococcus aureus ATCC 29213

-

-

-

PGT

Aquifex aeolicus

-

-

704207

PGT

Aquifex aeolicus

O66874

-

701437

PGT

Enterococcus faecalis

-

-

704163

PGT

Escherichia coli

-

-

704163, 735922

PGT

Escherichia coli

P02919

-

758901

PGT

Escherichia coli imp

-

-

-

PGT

Staphylococcus aureus

-

-

704163, 735922

PGT

Staphylococcus aureus ATCC 29213

-

-

-

SgtB

Staphylococcus aureus

-

-

758865

SgtB

Staphylococcus aureus

W8U4T4

-

759431