2.4.1.122: N-acetylgalactosaminide beta-1,3-galactosyltransferase

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For detailed information about N-acetylgalactosaminide beta-1,3-galactosyltransferase, go to the full flat file.

Reaction

Synonyms

3betaGal-T4, beta-galactosyltransferase, C1beta3GalT, C1GalT, C1GALT1, C1GalTA, Ce-T-synthase, core 1 beta1,3-galactosyltransferase, core 1 beta1,3-galactosyltrasferase 1, core 1 beta3-Gal-T, core 1 beta3-Gal-transferase, core 1 galactosyltransferase A, core 1 GalT, core 1 synthase, core 1 transferase, core 1 UDP-alpha-galactose (UDP-Gal):GalNAca1-Ser/Thr beta1,3-galactosyltransferase, core-1 beta3GalT, dC1beta3GalT1, dC1GalT1, EC 2.4.1.307, galactosyltransferase, galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, mucin-type core-1 beta1-3 galactosyltransferase, O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase, T-synthase, UDP-Gal:GalNAc-alpha-Ser/Thr beta3-galactosyltransferase, UDP-Gal:glycoprotein-alpha-GalNAc beta3 galactosyltransferase, UDP-Gal:N-acetylgalactosaminide mucin:beta1,3-galactosyltransferase, UDP-galactose:glycoprotein-alpha-GalNAc beta3-galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-galactosyltransferase, WbnJ

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase

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Results	in table
4	Activating Compound
2674	AA Sequence
3	Application
1	CAS Registry Number
15	Cloned(Commentary)
1053	Disease/ Diagnostics
1	Expression
21	General Information
1	General Stability
7	Inhibitors
10	KM Value [mM]
19	Localization
7	Metals/Ions
8	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
43	Organism
9	Pathway
2	PDB ID
9	pH Optimum
2	pH Range
2	Posttranslational Modification
1	Protein Variants
8	Purification (Commentary)
3	Reaction
3	Reaction Type
38	Reference
1	Renatured (Commentary)
72	Source Tissue
15	Specific Activity [micromol/min/mg]
1	Storage Stability
91	Substrates and Products (Substrate)
4	Subunits
64	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

Expression

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Expression on EC 2.4.1.122 - N-acetylgalactosaminide beta-1,3-galactosyltransferase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

real-time RT-PCR analysis shows that C1GALT1 messenger RNA expression is not significantly affected, implying that the effect of itraconazole on C1GALT1 protein levels might be through posttranslational modifications. Itraconazole increases ubiquitinated C1GALT1. C1GALT1 degradation induced by itraconazole is primarily through the proteasomal degradation pathway

Homo sapiens

Q9NS00

759356