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2.3.1.78: heparan-alpha-glucosaminide N-acetyltransferase

This is an abbreviated version!
For detailed information about heparan-alpha-glucosaminide N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.78

Reaction

acetyl-CoA
+
heparan sulfate alpha-D-glucosaminide
=
CoA
+
heparan sulfate N-acetyl-alpha-D-glucosaminide

Synonyms

acetyl-CoA:alpha-glucosaminide N-acetyltransferase, acetyl-coenzyme A-alpha-glucosaminide N-acetyltransferase, acetyl-coenzyme A:alpha-glucosaminide N-acetyltransferase, acetyl-coenzyme:alpha-D-2-amino-glucosamine transferase, acetyltransferase, alpha-glucosaminide, acetyl–coenzyme A:alpha-glucosaminide N-acetyltransferase, GNAT, heparan sulfate acetyl-CoA: alpha-glucosaminide N-acetyltransferase, heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase, HGSNAT, TMEM76, transmembrane protein 76

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.78 heparan-alpha-glucosaminide N-acetyltransferase

Inhibitors

Inhibitors on EC 2.3.1.78 - heparan-alpha-glucosaminide N-acetyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
membrane-bound enzyme is insensitive, solubilized enzyme is inactivated
acetyl-CoA
-
-
alpha-D-glucosamine 6-phosphate
-
weak
alpha-methyl-D-glucose
-
weak
cellobiose
-
weak
chitosan
-
-
coenzyme A
D-glucosamine
desulfo-CoA
-
competitive against acetyl-CoA
diethyl dicarbonate
-
reversible by incubation with hydroxylamine, binds a histidine residue at the active site
dithiothreitol
-
solubilized protein
Hg2+
-
complete inhibition
maltose
-
weak
N-acetyl-alpha-D-glucosamine
-
-
N-acetyl-beta-D-glucosamine
N-bromosuccinimide
-
binds a histidine residue at the active site
N-laurylsarcosine
-
1%
p-chloromercuribenzoate
sucrose
-
weak
Zwittergent
-
1%
-
additional information
-