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2.3.1.244: 2-methylbutanoate polyketide synthase

This is an abbreviated version!
For detailed information about 2-methylbutanoate polyketide synthase, go to the full flat file.

Reaction

2 malonyl-CoA +

[2-methylbutanoate polyketide synthase]
+ 2 NADPH + 3 H+ +
S-adenosyl-L-methionine
=
(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]
+ 2 CoA + 2 CO2 + 2 NADP+ +
S-adenosyl-L-homocysteine
+
H2O

Synonyms

LDKS, LocF, lovastatin diketide synthase, LovF

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.244 2-methylbutanoate polyketide synthase

Application

Application on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
using a multivector expression system in Saccharomyces cerevisiae, two natural statins from two fungal species, i.e., lovastatin from Aspergillus terreus and FR901512 from Xylaria grammica are reconstituted, but also new statin structures by mixing their genes