2.3.1.244: 2-methylbutanoate polyketide synthase
This is an abbreviated version!
For detailed information about 2-methylbutanoate polyketide synthase, go to the full flat file.
Reaction
2 malonyl-CoA + + 2 NADPH + 3 H+ + = + 2 CoA + 2 CO2 + 2 NADP+ + +
Synonyms
LDKS, LocF, lovastatin diketide synthase, LovF
ECTree
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Application
Application on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase
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synthesis
using a multivector expression system in Saccharomyces cerevisiae, two natural statins from two fungal species, i.e., lovastatin from Aspergillus terreus and FR901512 from Xylaria grammica are reconstituted, but also new statin structures by mixing their genes