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2.3.1.220: 2,4,6-trihydroxybenzophenone synthase

This is an abbreviated version!
For detailed information about 2,4,6-trihydroxybenzophenone synthase, go to the full flat file.

Word Map on EC 2.3.1.220

Reaction

3 malonyl-CoA +

benzoyl-CoA
= 4 CoA +
2,4,6-trihydroxybenzophenone
 + 3 CO2

Synonyms

benzophenone synthase, BPS, HaBPS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.220 2,4,6-trihydroxybenzophenone synthase

Crystallization

Crystallization on EC 2.3.1.220 - 2,4,6-trihydroxybenzophenone synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging-drop vapor-diffusion method using buffered protein solutions (10-15 mg/ml) mixed with equal volumes of the reservoir solution and incubated at 4°C. Crystal structures of biphenyl synthase from Malus domestica and benzophenone synthase from Hypericum androsaemum are compared with the structure of an archetypal type III polyketide synthase - chalcone synthase from Malus domestica
hanging-drop vapor-diffusion method, incubation at 4°C. Crystal structures of biphenyl synthase from Malusx02domestica and benzophenone synthase from Hypericum androsaemum are compared with the structure of an archetypal type III polyketide synthase: chalcone synthase from Malus domestica. Both biphenyl synthase and benzophenone synthase contain mutations that reshape their active-site cavities to prevent the binding of 4-coumaroyl-CoA and to favor the binding of small hydrophobic substrates. The active-site cavities of biphenyl synthase and benzophenone synthase also contain a novel pocket associated with their chain-elongation and cyclization reactions