2.3.1.137: carnitine O-octanoyltransferase

This is an abbreviated version!
For detailed information about carnitine O-octanoyltransferase, go to the full flat file.

Reaction

Synonyms

carnitine acyltransferase, Carnitine medium-chain acyltransferase, carnitine octanoyltransferase, COT, CRAT, CrOT, easily solubilized mitochondrial carnitine palmitoyltransferase, medium-chain carnitine acyltransferase, medium-chain/long-chain carnitine acyltransferase, More, overt mitochondrial carnitine palmitoyltransferase, short-chain carnitine acyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.137 carnitine O-octanoyltransferase

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Results	in table
1	Activating Compound
21	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
1	General Information
2	General Stability
35	Inhibitors
5	Ki Value [mM]
63	KM Value [mM]
84	Localization
13	Molecular Weight [Da]
131	Natural Substrates/ Products (Substrates)
563	Organism
8	PDB ID
3	pH Optimum
2	pH Range
9	Protein Variants
14	Purification (Commentary)
4	Reaction
3	Reaction Type
64	Reference
75	Source Tissue
3	Specific Activity [micromol/min/mg]
6	Storage Stability
304	Substrates and Products (Substrate)
9	Subunits
46	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Disease

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Disease on EC 2.3.1.137 - carnitine O-octanoyltransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Alzheimer Disease

Carnitine acyltransferases are not changed in Alzheimer disease.

9651134

Cardiomyopathies

Cardiac carnitine acyltransferase activities in exercised normal and dystrophic hamsters.

1783040

carnitine o-palmitoyltransferase deficiency

Carnitine acyltransferases in normal human skeletal muscle and in muscle of patients with carnitine palmitoyltransferase deficiency.

1822803

Cholestasis

Inhibition of carnitine acyltransferase activities by bile acids in rat liver peroxisomes.

1571363

Diabetes Mellitus

[14C]palmitate uptake in isolated rat liver mitochondria: effects of fasting, diabetes mellitus, and inhibitors of carnitine acyltransferase.

99482

Hyperthyroidism

Development of ketonemia in fasting patients with hyperthyroidism.

284713

Ischemic Contracture

Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia.

8261598

Ketosis

Development of ketonemia in fasting patients with hyperthyroidism.

284713

Myocardial Ischemia

Delineation of the influence of propionylcarnitine on the accumulation of long-chain acylcarnitines and electrophysiologic derangements evoked by hypoxia in canine myocardium.

2031873

Myocardial Ischemia

Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis.

7543431

Peroxisomal Disorders

Peroxisomal proliferation in heart and liver of mice receiving chlorpromazine, ethyl 2(5(4-chlorophenyl)pentyl) oxiran-2-carboxylic acid or high fat diet: a biochemical and morphometrical comparative study.

3431962

Pregnancy, Prolonged

Hepatic mitochondrial fatty acid oxidation during the perinatal period in the rat.

6852351

Starvation

Effect of carnitine on branched-chain amino acid oxidation by liver and skeletal muscle.

645901

Starvation

Hepatic mitochondrial fatty acid oxidation during the perinatal period in the rat.

6852351

Starvation

Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon.

1133169

Tachycardia, Ventricular

Recent insights pertaining to sarcolemmal phospholipid alterations underlying arrhythmogenesis in the ischemic heart.

8269301

Tachycardia, Ventricular

Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis.

7543431

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