1.2.1.95: L-2-aminoadipate reductase
This is an abbreviated version!
For detailed information about L-2-aminoadipate reductase, go to the full flat file.
Word Map on EC 1.2.1.95
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1.2.1.95
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albicans
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schizosaccharomyces
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saccharopine
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pombe
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chrysogenum
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phosphopantetheinylate
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l-lysine
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homoisocitrate
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homocitrate
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isofunctional
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lysine-supplemented
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pptases
- 1.2.1.95
- albicans
-
schizosaccharomyces
- saccharopine
- pombe
- chrysogenum
-
phosphopantetheinylate
- l-lysine
- homoisocitrate
- homocitrate
-
isofunctional
-
lysine-supplemented
- pptases
Reaction
Synonyms
AAR, AarA, AasS, alpha-AAR, alpha-aminoadipate delta-semialdehyde synthase, alpha-aminoadipate reductase, L-alpha-aminoadipic acid reductase, Lys1+, LYS2, Nps3
ECTree
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Systematic Name
Systematic Name on EC 1.2.1.95 - L-2-aminoadipate reductase
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(S)-2-amino-6-oxohexanoate:NADP+ oxidoreductase (ATP-forming)
This enzyme, characterized from the yeast Saccharomyces cerevisiae, catalyses the reduction of L-2-aminoadipate to (S)-2-amino-6-oxohexanoate during L-lysine biosynthesis. An adenylation domain activates the substrate at the expense of ATP hydrolysis, and forms L-2-aminoadipate adenylate, which is attached to a peptidyl-carrier protein (PCP) domain. Binding of NADPH results in reductive cleavage of the acyl-S-enzyme intermediate, releasing (S)-2-amino-6-oxohexanoate. Different from EC 1.2.1.31, L-aminoadipate-semialdehyde dehydrogenase, which catalyses a similar transformation in the opposite direction without ATP hydrolysis.