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1.14.14.151: premnaspirodiene oxygenase

This is an abbreviated version!
For detailed information about premnaspirodiene oxygenase, go to the full flat file.

Word Map on EC 1.14.14.151

Reaction

(-)-vetispiradiene
+ 2 [reduced NADPH-hemoprotein reductase] + 2 O2 =
solavetivone
 + 2 [oxidized NADPH-hemoprotein reductase] + 3 H2O

Synonyms

CYP71D55, EC 1.14.13.121, HPO, OsCYP71

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.151 premnaspirodiene oxygenase

Substrates Products

Substrates Products on EC 1.14.14.151 - premnaspirodiene oxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-valencene + [reduced NADPH-hemoprotein reductase] + O2
alpha-nootkatol + beta-nootkatol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
enzyme HPO-mediated biohydroxylation of (+)-valencene
-
-
?
(-)-vetispiradiene + [reduced NADPH-hemoprotein reductase] + O2
solavetivol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
solavetivol is also named premnaspirodien-2alpha-ol or (2S,4R,5S,7R)-spirovetiva-1(10),11(12)-dien-2-ol
-
?
4-epi-eremophilene + [reduced NADPH-hemoprotein reductase] + O2
4-epieremophilen-2beta-ol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
?
5-epiaristolochene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
2beta-hydroxy-5-epiaristolochene + 1beta-hydroxy-5-epiaristolochene + 3alpha-hydroxy-5-epiaristolochene + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O
show the reaction diagram
substrate affinity for 5-epiaristolochene is 2-4times lower than that for valencene or (-)-premnaspirodiene, respectively. HPO catalyzes the conversion of 5-epiaristolochene to four mono-hydroxylated products with 2beta-hydroxy-epiaristolochene comprising greater than 80% of the reaction products, 1beta-hydroxy-epiaristolochene about 5%, 3alpha-hydroxy-epiaristolochene less than 2%, and an unknown mono-hydroxylated product of about 20%
-
-
?
cedr-8-ene + [reduced NADPH-hemoprotein reductase] + O2
cedr-8-en-15-ol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
?
valencene + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
alpha-nootkatol + beta-nootkatol + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
-
-
-
?
additional information
?
-