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1.14.11.69: [histone H3]-trimethyl-L-lysine36 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.69

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-N6-methyl-L-lysine36
 + 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AN1060, CG15835, CG33182, dKDM4A, Dmel\Kdm4A, DNA damage-responsive transcriptional repressor, H3K36 demethylase, H3K36 histone demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, JHDM3A, JHDM3B, JmjC demethylase, JmjC histone lysine demethylase, JmjC protein, JMJD-2, JMJD2A, JMJD2A demethylase, JMJD2B, JMJD2C, jumonji domain containing 2A, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM, KDM4, KDM4A, KDM4A demethylase, KDM4A lysine demethylase, KDM4A,, KDM4A/JMJD2A, KDM4B, Kdm4c, KdmA, LD33386, lysine trimethyl-specific JmjC histone demethylase, lysine-specific demethylase 4A, More, Rph1, Rph1/KDM4, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylase

Activating Compound

Activating Compound on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ascorbate
fisetin
fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin
heterochromatin protein 1
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predominant localization to centric heterochromatin. HP1a, when resident near centromeres, plays a role in the gene silencing associated with heterochromatin packaging. HP1a binding, two molecules HP1a per enzyme molecule, stimulates demethylation of H3K36me2 and H3K36me3 by dKDM4a, mechanism, overview. HP1a mutant V26M is inactive
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HP1 a protein
HP1a, encoded by the Su(var)2-5 gene and involved in the establishment and maintenance of higher-order structure of heterochromatin, stimulates the histone H3K36 demethylation activity of dKDM4A, and this stimulation depends on the H3K9me-binding motif of HP1a. HP1a and dKDM4A interact with each other, and loss of HP1a leads to an increased level of histone H3K36me3. The CSD of HP1a and a consensus HP1-interacting PxVxL motif in dKDM4A are responsible for the HP1a-dKDM4A interaction
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HP1a
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HP1a targets the H3K36 demethylase dKDM4A to heterochromatic genes, it is required for dKDM4A-mediated H3K36me3 demethylation at a subset of heterochromatic genes. Demethylation activity of dKDM4A at euchromatin is independent of HP1a targeting
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