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EC Number Crystallization (Commentary)
Display the reaction diagram Show all sequences 1.4.1.28homology modeling of structure in complex with NADH. Residue S68 of AmDH forms a hydrogen bond with the substrate hydroxyl group, and there are also hydrophobic interactions between the substrate and the side chains of V116 and L261
Display the reaction diagram Show all sequences 1.4.1.28homology modeling of structure. The coordination of the amine group to E108 holds the tetrahedral carbon of the substrate bearing the amine
Display the reaction diagram Show all sequences 1.4.1.28structure without substrate but bound to the cofactor NAD+, and a model of the ternary complex with product (2R,4S)-2,4-diaminopentanoate in the closed conformation. The active site features residues Glu102, Val134, Asn135, Arg161, Asn163, Phe168, Val172, Gln176, His197, Ile198, His264, Gln266, Gly299 and Thr303
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