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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32more the enzyme Hrt1 is a RING-type E3 for Rub1 ligation to Cdc53 Saccharomyces cerevisiae ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32more ALF4 binds to the enzyme and inhibits the activity of SCFTIR1, an E3 ligase responsible for degradation of the Aux/IAA transcriptional repressors Arabidopsis thaliana ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32more Rbx1 is a subunit of the related SCF (Skp1-Cdc53/Cul1-F-box protein) and von Hippel-Lindau (VHL) tumor suppressor (elongin BC-Cul2-VHL) E3 ubiquitin ligase complexes, where it functions as a component of Cdc53/Rbx1 and Cul2/ Rbx1 modules that activate ubiquitination of target proteins by the E2 ubiquitin-conjugating enzymes Cdc34 and Ubc5 Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32more the NEDD8 conjugating enzyme UBE2M binds specifically to RBX1 Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32more conjugation of RBX1 to NEDD8 substantially stimulates the reaction, by nearly 2000fold, activating both substrate-priming and chain-elongation reactions. Presence of NEDD8 coordinates ubiquitin ligation assembly Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32more Ubc12, a NEDD8-specific E2 conjugating enzyme, is a substrate for auto-neddylation. Protease SENP8/DEN1 counteracts Ubc12 autoneddylation, and aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components is observed in SENP8-deficient cells Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32[E2 NEDD8-conjugating enzyme Ubc12]-S-[NEDD8-protein]-yl-L-cysteine + [cullin]-L-lysine - Homo sapiens [E2 NEDD8-conjugating enzyme Ubc12]-L-cysteine + [cullin]-N6-[NEDD8-protein]-yl-L-lysine - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 1]-L-lysine - Mus musculus [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 1]-N6-[NEDD8-protein]-yl-L-lysine - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 1]-L-lysine - Homo sapiens [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 1]-N6-[NEDD8-protein]-yl-L-lysine - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.32[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 1]-L-lysine - Arabidopsis thaliana [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 1]-N6-[NEDD8-protein]-yl-L-lysine - ?
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