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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] - Drosophila sp. (in: flies) 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] - ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] - Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] - ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] - Homo sapiens 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] - ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] in the absence of ATP, S-adenosyl-L-methionine donates three methyl groups to form the trimethylamine and converts the intermediate intermediate to diphthine. The methyltransferase activity is specific for a single soluble cytosolic protein, translation elongation factor 2 Cricetulus griseus 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] - ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the relevant histidine of elongation factor 2 is His699 in Saccharomyces cerevisiae Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] eukaryotic diphthine synthase, Dph5, is a promiscuous methyltransferase that catalyzes an extraordinary N,O-tetramethylation of 2-(3-carboxy-3-aminopropyl)-L-histidine to yield diphthine methyl ester. This compound is an intermediates in the biosynthesis of the post-translationally modified histidine residue diphthamide, a unique and essential residue part of the eukaryotic elongation factor 2 (eEF2) Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] - ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] in eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network. Diphthamide is the target for diphtheria toxin and related lethal ADP ribosylases, which collectively kill cells by inactivating the essential translocase function of EF2 during mRNA translation and protein biosynthesis Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] - ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] post-translational modification of eukaryotic elongation factor 2 (eEF2) Drosophila sp. (in: flies) 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] - ?
Display the reaction diagram Show all sequences 2.1.1.3144 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the enzyme is involved in the diphthamide modification pathway Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] - ?
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