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Results 1 - 10 of 26 > >>
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.2992 S-adenosyl-L-methionine + PPKRIA mono- and dimethylation by NTMT2 Homo sapiens 2 S-adenosyl-L-homocysteine + ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.2993 S-adenosyl-L-methionine + GPKRIA mono-, di-, and trimethylation by NTMT2 Homo sapiens 3 S-adenosyl-L-homocysteine + ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299more NRMT2 exhibits monomethylase activity in vitro. Isozymes NRMT1 and NRMT2 can interact both in vitro and in vivo, modeling of NRMT1 and NRMT2 interactions. No activity with the MYL9 peptide SSKRAKAKTTKKRP Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299more NTMT2 is a mono-methyltransferase, substrate specificity, overview. But NTMT2 is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide, otherwise it is predominantly a mono-methyltransferase. The residue N89 of NTMT2 serves as a gatekeeper residue that regulates the binding of unmethylated versus mono-methylated substrate peptide.The substrate peptide is deeply inserted into the binding pocket through hydrophilic and hydrophobic interactions, and the alpha-amine of the first residue (S1) points towards the sulfur atom of SAH. In the NTMT2 complex, S1 fits snugly into the channel, where the main-chain O atom is anchored by N223 in NTMT2 (N168 in NTMT1, EC 2.1.1.244) through hydrogen bonding. No activity with peptides TPKRIA, VPKRIA, IPKRIA, DPKRIA, EPKRIA, NPKRIA, and QPKRIA Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299more the substrate recognition motif is X-P-K/R. Although NTMT2 is proposed to be a monomethylase, it can also fully methylate both GPKRIA and PPKRIA peptides, but to a low level. NTMT2 is able to methylate hexamer peptides Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine - Homo sapiens N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299S-adenosyl-L-methionine + APKRIA monomethylation by NTMT2 Homo sapiens S-adenosyl-L-homocysteine + ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299S-adenosyl-L-methionine + CPKRIA monomethylation by NTMT2 Homo sapiens S-adenosyl-L-homocysteine + ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299S-adenosyl-L-methionine + FPKRIA monomethylation by NTMT2 Homo sapiens S-adenosyl-L-homocysteine + ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299S-adenosyl-L-methionine + HPKRIA monomethylation by NTMT2 Homo sapiens S-adenosyl-L-homocysteine + ? - ?
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