EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.204 | more |
DNMT2 induces a conformational change in the tRNA of the DNMT2-tRNA complex |
Homo sapiens |
? |
- |
? |
2.1.1.204 | more |
Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs |
Dictyostelium discoideum |
? |
- |
? |
2.1.1.204 | more |
Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs. Pmt1 shows a striking selectivity for tRNAAsp methylation, which distinguishes Pmt1 from other Dnmt2 homologues. C34 of tRNAPro is a Pmt1- and queuosine-independent tRNA methylation site in Schizosaccharomyces pombe |
Schizosaccharomyces pombe |
? |
- |
? |
2.1.1.204 | more |
DNMT2 functions primarily, if not exclusively, as a cytosine 5-methylation RNA methyltransferase with three verified tRNA targets: tRNAAsp, tRNAGly and tRNAVal |
Homo sapiens |
? |
- |
? |
2.1.1.204 | more |
Dnmt2 methylates C38 of tRNA in the bone marrow and modulates the stability and fragmentation of substrate tRNAs |
Mus musculus |
? |
- |
? |
2.1.1.204 | more |
the enzyme DNMT2 is responsible for methylation of cytosine 38 in the anticodon loop of aspartic acid transfer RNA instead of transferring methyl group to the cytosine residues of DNA |
Homo sapiens |
? |
- |
? |
2.1.1.204 | more |
the enzyme DNMT2 is responsible for methylation of cytosine 38 in the anticodon loop of aspartic acid transfer RNA instead of transferring methyl group to the cytosine residues of DNA |
Bos taurus |
? |
- |
? |
2.1.1.204 | more |
the enzyme DNMT2 is responsible for methylation of cytosine 38 in the anticodon loop of aspartic acid transfer RNA instead of transferring methyl group to the cytosine residues of DNA |
Mus musculus |
? |
- |
? |
2.1.1.204 | more |
development and evaluation of 5-azacytidine-mediated RNA immunoprecipitation, a mechanism-based technique in nine steps that exploits the covalent bond formed between an RNA methyltransferase and the cytidine analogue 5-azacytidine to recover RNA targets by immunoprecipitation, overview. High frequency of C>G transversions at the cytosine residues targeted by the enzyme, allowing identification of the specific methylated cytosine(s) in target RNAs. tRNAGly(GCC) bears one DNMT2 target site (C38) |
Homo sapiens |
? |
- |
? |
2.1.1.204 | more |
in vitro methylation activity on tRNAAsp and, to a lesser extent, tRNAGlu. No methylation activity with C38-containing tRNAs for histidine, glutamate, and valine |
Schizosaccharomyces pombe |
? |
- |
? |