EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.1.1.231 | (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ |
- |
Oryctolagus cuniculus |
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH |
- |
? |
| 1.1.1.231 | (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ |
i.e. prostaglandin I2, prostacyclin |
Oryctolagus cuniculus |
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH |
the product is not stable and not available for analysis of the reverse reaction |
? |
| 1.1.1.231 | (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ |
i.e. prostaglandin I2, prostacyclin |
Oryctolagus cuniculus |
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH |
i.e. 15-keto prostaglandin I2 |
? |
| 1.1.1.231 | 4-benzoylpyridine + NADP+ |
recombinant forms CHCR1, CHCR2 |
Cricetulus griseus |
? |
- |
? |
| 1.1.1.231 | 4-nitrobenzaldehyde + NADP+ |
recombinant forms CHCR1, CHCR2 |
Cricetulus griseus |
4-nitrobenzoate + NADPH |
- |
? |
| 1.1.1.231 | 4-nitrobenzaldehyde + NADP+ |
more rapid reaction than with prostacyclin |
Oryctolagus cuniculus |
4-nitrobenzoate + NADPH |
- |
? |
| 1.1.1.231 | 6-keto-prostaglandin F1alpha + NADP+ |
at 1.8% the reaction rate of prostaglandin I2 |
Oryctolagus cuniculus |
6,15-diketoprostaglandin F2alpha + NADPH |
- |
? |
| 1.1.1.231 | menadione + NADP+ |
more rapid reaction than with prostacyclin |
Oryctolagus cuniculus |
? |
- |
? |
| 1.1.1.231 | more |
comparison of 3 15-hydroxyproastaglandin dehydrogenases with varying amounts of 9-ketoprostaglandin reductase activity |
Homo sapiens |
? |
- |
? |
| 1.1.1.231 | more |
enzyme catalyzes reduction of 9-keto group in prostaglandin E2 at less than 1% the rate of prostaglandin I2 oxidation |
Oryctolagus cuniculus |
? |
- |
? |
