EC Number   |
General Information |
Reference |
|---|
   2.3.1.B46 | evolution |
the enzyme belongs to the MBOAT family |
-, 756102, 757632 |
| 2.3.1.B46 | malfunction |
incorporation of exogenous PUFA into PI of the living worms and LPIAT activity in the microsomes are greatly reduced in mboa-7 mutants. Furthermore, the membrane fractions of transgenic worms expressing recombinant MBOA-7 and its human homologue exhibit remarkably increased LPIAT activity. Gene mboa-7 mutants have significantly lower eicosapentaenoic acid (EPA) levels in phosphatidylinositol (PI), and they exhibit larval arrest and egg-laying defects. Fatty acid composition of wild-type and mboa-7 mutants, overview |
-, 757632 |
| 2.3.1.B46 | malfunction |
LPIAT1 deficiency induces abnormal brain morphology, delays neural migration, and reduces neurite outgrowth in mice. The size of LPIAT1-KO mice is significantly smaller than that of their littermates. The frequency of mice carrying the knockout mutation is lower than that expected by Mendelian genetics. Rs641738, a polymorphism in the LPIAT1 (MBOAT7) locus is reported to associate with hepatic inflammation and increased risk of fibrosis, nonalcoholic fatty liver disease, and alcohol related cirrhosis. This variant decreases LPIAT1 expression in the liver and changes PI compositions in the plasma. Other mutations are also reported to lead to intellectual disability, suggesting the importance of AA-containing phosphatidylinositol in the disease development |
756102 |
| 2.3.1.B46 | metabolism |
phospholipase A2 (PLA2) plays a role in membrane phospholipid remodeling by coupling with re-acylation processes mediated by lysophospholipid acyltransferases (LPLATs) to generate sn-1/sn-2 fatty acid asymmetry of phospholipids. Lysophospholipids are acylated by LPLAT to generate phospholipids phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglycerol (PG), and cardiolipin (CL) by LPLATs. In the Kennedy pathway, glycerol-3-phosphate (G3P) is first acylated by glycerol-phosphate acyltransferase (GPAT) to form lyso-PA (LPA), which is subsequently converted to PA by LPA-acyltransferase (LPAAT) |
756102 |
| 2.3.1.B46 | physiological function |
the enzyme is required for selective incorporation of polyunsaturated fatty acids (PUFAs) into phosphatidylinositol. Phosphatidylinositol (PI) is a component of membrane phospholipids, and it functions both as a signaling molecule and as a compartment-specific localization signal in the form of polyphosphoinositides. Arachidonic acid (AA) is the predominant fatty acid in the sn-2 position of PI in mammals. LysoPI acyltransferase (LPIAT) is thought to catalyze formation of AA-containing PI |
757632 |
| 2.3.1.B46 | physiological function |
the enzyme is required for selective incorporation of polyunsaturated fatty acids (PUFAs) into phosphatidylinositol. Phosphatidylinositol (PI) is a component of membrane phospholipids, and it functions both as a signaling molecule and as a compartment-specific localization signal in the form of polyphosphoinositides. Arachidonic acid (AA) is the predominant fatty acid in the sn-2 position of PI in mammals. LysoPI acyltransferase (LPIAT) is thought to catalyze formation of AA-containing PI. In Caenorhabditis elegans, eicosapentaenoic acid (EPA) instead of AA is the predominant fatty acid in PI |
-, 757632 |
