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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299evolution structural comparison of isozymes NTMT1 and NTMT2, structural alignment of NTMT1 (PDB ID 5E1B) and NTMT2, overview. NTMT1 and NTMT2 employ a similar substrate recognition mode. NTMT2 is a SAM-dependent class I methyltransferase 756502
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299evolution the enzyme belongs to the methyltransferase like (METTL) family of class I methyltransferases containing seven-beta-strand methyltransferase motifs and Rossman folds for binding SAM. The N-terminal methyltransferase homologs NRMT1 (N-terminal RCC1 methyltransferase 1) and NRMT2 (N-terminal RCC1 methyltransferase 2), which following cleavage of the initiating methionine, methylate the alpha-amine of the first N-terminal residue of their substrates. NRMT1 and NRMT2 are 50% identical and 75% similar and share an N-terminal X-P-K consensus sequence. Although structurally similar, they differ in their catalytic activities 758296
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299malfunction the N209I endometrial and P211S lung cancer mutants decrease the trimethylation level of RCC1, whereas the Q144H lung cancer mutant increases the trimethylation level of RCC1 with minimal levels of mono- and dimethylated RCC1. For NTMT2, the V224L breast cancer mutant shows marginal methylation activity for methylation states. Those data infer that methylation levels may play different roles in different cancers 756463
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299metabolism protein alpha-N-terminal methylation is catalyzed by prokaryotic and eukaryotic protein N-terminal methyltransferases. The prevalent occurrence of this methylation in ribosomes, myosin, and histones implies its function in protein-protein interactions. Functions of methylated glycine, alanine, and serine, overview 756463
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299more analysis of crystal structures of NRMT1 and NRMT2 (PDB IDs 2EX4 and 5UBB, determined to 1.75 and 2.0 A, respectively), homology modeling. Modeling of NRMT1 and NRMT2 heterotrimer, interaction analysis, overview 758296
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299more substrate and ligand binding structures of NTMT1 (EC 2.1.1.244) and NTMT2, and proposed catalytic mechanism of NTMT2, overview 756502
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299more substrate recognition and catalytic mechanisms, overview 756463
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299physiological function isozyme NRMT2 expression activates isozyme NRMT1 activity, not through priming, but by increasing its stability and substrate affinity. NRMT2 overexpression cannot rescue NRMT1 knockout phenotypes 758296
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.299physiological function protein methylation participates in regulation of a broad spectrum of cellular processes. Besides the extensively studied protein lysine/arginine methylation, the addition of a methyl group at the free alpha-N-termini of proteins represents a unique mode of post-translational modification 756502
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