EC Number   |
General Information |
Reference |
|---|
   1.17.3.2 | evolution |
analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview |
744744 |
| 1.17.3.2 | malfunction |
deletion mutant exhibits less than 1% of the wild-type strain activity towards xanthine and hypoxanthine under inducible conditions and both strains show no activity after cultivation without inducer (adenine) |
727706 |
| 1.17.3.2 | malfunction |
the enzyme is a key enzyme in th epathogenesis of hyperuricemia |
706363 |
| 1.17.3.2 | malfunction |
upregulation of seric XO activity through infection with Ichthyophthirius multifiliis leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Uric acid induces the release of pro-inflammatory and pro-oxidative mediators, such as nitric oxide (NOx) and reactive oxygen species (ROS), which contribute directly to disease pathogenesis |
745473 |
| 1.17.3.2 | malfunction |
upregulation of splenic xanthine oxidase activity contributes to disease pathogenesis of Aeromonas caviae infection, as well as whether it may be considered a pathway involved in reactive oxygen species (ROS) and nitric oxide (NO) production. Excessive uric acid induces the release of pro-inflammatory mediators, such as ROS and NOx, which contribute to disease pathophysiology, in spleen tissue they contribute to oxidation and inflammation of the tissue |
745709 |
| 1.17.3.2 | metabolism |
effects of enzyme inhibition in inflammatory macrophages, overview |
-, 715663 |
| 1.17.3.2 | metabolism |
purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid |
744744 |
| 1.17.3.2 | metabolism |
purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purinesalvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid |
744744 |
| 1.17.3.2 | metabolism |
the enzyme plays an important role in the metabolism of many xenobiotics and drugs, such as purines and pyrimidines, mercaptopurine and azathioprine, thiazides, pyrazinamide, and acyclovir |
702182 |
| 1.17.3.2 | metabolism |
xanthine oxidase is a key enzyme in the purine metabolic pathway, catalysing the oxidation of hypoxanthine to uric acid |
705237 |
