EC Number   |
General Information |
Reference |
|---|
    1.14.15.4 | evolution |
although the active site pocket is lined by identical residues between CYP11B isoforms, most of the divergent residues that confer additional 18-oxidase activity of aldosterone synthase are located in the I-helix, vicinity of the O2 activation path and loops around the H-helix, affecting an egress channel closure required for retaining intermediates in the active site |
725981 |
| 1.14.15.4 | malfunction |
familial hyperaldosteronism type I is caused by the unequal recombination between the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 genes, resulting in the generation of a CYP11B1/B2 chimeric gene and abnormal adrenal aldosterone production, which leads to severe hypertension and an elevated frequency of stroke at a young age |
726468 |
| 1.14.15.4 | malfunction |
overproduction of aldosterone in the adrenal gland can lead to hypertension, a major cause of heart disease and stroke |
726012 |
| 1.14.15.4 | metabolism |
aldosterone synthase, CYP11B2, is the key enzyme of mineralocorticoid biosynthesis and its malfunction is involved in hyperaldosteronism, congestive heart failure, and myocardial fibrosis |
712715 |
| 1.14.15.4 | metabolism |
CYP11B1 is a key enzyme in the biosynthesis of cortisol. CYP11B2 catalyzes the last three steps of aldosterone biosynthesis |
711420 |
| 1.14.15.4 | metabolism |
human aldosterone synthase is responsible for the biosynthesis of aldosterone from 11-deoxycorticosterone in a sequential three-step reaction with two intermediates, corticosterone and 18-hydroxycorticosterone |
725828 |
| 1.14.15.4 | metabolism |
very-low-density lipoprotein mediates transcriptional upregulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways, e.g. partially through scavenger receptor class B type I. Aldosterone, apart from its role in fluid and electrolyte homeostasis, is implicated in insulin resistance and myocardial fibrosis. Impact of VLDL as a potential risk factor for aldosterone-mediated cardiovascular injury in diabetes mellitus, intracellular mechanism, overview |
724701 |
| 1.14.15.4 | more |
a hydrophobic cavity with specific features is associated with corticosteroid recognition, substrate binding mode, overview |
725981 |
| 1.14.15.4 | more |
homology modeling and molecular docking of CYP11B2, overview |
725828 |
| 1.14.15.4 | more |
molecular modelling of CYP11B1 and CYP11B1/B2 chimeric proteins and steroids docking, overview |
726468 |
