EC Number |
Expression |
Reference |
---|
1.14.14.18 | down |
expression of isoform Hmox2a is significantly reduced in male gill samples in response to the 96 hour cadmium exposure |
746533 |
1.14.14.18 | down |
HO-1 expression is reduced upon differentiation of cytotrophoblasts into extravillous trophoblasts. Knock down of endogenous HO-1 in BeWo cells using retroviral transduction with a miRNA adapted retroviral vector targeting human HO-1 sequence |
703461 |
1.14.14.18 | down |
HO-1 induction after hemoglobin treatment is decreased by about half by MEK inhibitors U0126 and SL327, and is completely prevented by the direct ERK inhibitor FR180204 |
705913 |
1.14.14.18 | down |
lipopolysaccharide downregulates isoform HO-1 in primary human peripheral blood mononuclear cells, CD14+ monocytes, macrophages, dendritic cells, and granulocytes |
733904 |
1.14.14.18 | down |
small interfering RNA-mediated knock-down of Nrf-2 significantly inhibits surfactin-induced HO-1 expression. Inhibition of phosphoinositide 3-kinase/Akt and extracellular signal-regulated kinase significantly decreased surfactin-induced HO-1 expression, mechanism of surfactin, overview |
714707 |
1.14.14.18 | up |
21 h treatment with 0.05-0.2 mM docosahexaenoic acid enhances isoform HO-1 expression through transcriptional regulation in human cancer cells. Docosahexaenoic acid induces Bach1 protein degradation, thereby enhancing the transcriptional factor Nrf2-mediated isoform HO-1 gene transcription |
734531 |
1.14.14.18 | up |
apoptotic cell supernatants provoke a biphasic up-regulation of HO-1. Although the first phase of HO-1 induction at 6 h is accomplished by apoptotic cell-derived sphingosine-1-phosphate acting via sphingosine-1-phosphate receptor 1, the second wave of HO-1 induction at 24 h is attributed to autocrine signaling of vascular endothelial growth factor A, whose expression and release are facilitated by sphingosine-1-phosphate |
705614 |
1.14.14.18 | up |
cell treatment with Salvia plebeia methanolic extract significantly induces the expression of hemeoxygenase-1 |
734381 |
1.14.14.18 | up |
expression of Hmox1a, Hmox1b and biliverdin reductase b is significantly induced in zebrafish eleutheroembryos in response to pro-oxidants cadmium, hemin and tert-butylhydroquinone |
746533 |
1.14.14.18 | up |
expression of isoforms Hmox1a, Hmox2a and Hmox2b is significantly induced in male liver tissues in response to 96 hour cadmium exposure (20 microM). Hmox2a and Hmox2b are significantly induced in male brain samples |
746533 |