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EC Number Posttranslational Modification Commentary Reference
Show all pathways known for 1.4.1.3Display the reaction diagram Show all sequences 1.4.1.3more lysine methylation not found 723055
Show all pathways known for 1.4.1.3Display the reaction diagram Show all sequences 1.4.1.3more the ADP-ribosylation of glutamate dehydrogenase is catalyzed by Sirt4, and downregulates the TCA cycle. In the ternary complex model of Sirt4-NAD+-GDH, the acetylated lysine 171 of GDH is located close to NAD+. This suggests a possible mechanism underlying the ADP-ribosylation at cysteine 172, which may occur through a transient intermediate with ADP-ribosylation at the acetylated lysine 171 762936
Show all pathways known for 1.4.1.3Display the reaction diagram Show all sequences 1.4.1.3proteolytic modification limited trypsin proteolysis removes a 39 amino acid peptide from the enzyme 391598
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