EC Number   |
Application |
Reference |
|---|
   2.1.1.72 | analysis |
computational analysis of a published Dam knockout microarray alongside other publicly available |
676746 |
| 2.1.1.72 | analysis |
Dam alters the Ca2+ regulation of Yop secretion but does not affect the temperature regulation of Yop/Ysc expression, in Dam-overproducing strains transcription of the lcrGV and yopN-tyeA operons is slightly upregulated, but LcrG is absent from lysates, while the amounts of YopN and TyeA are not changed, clpXP expression increases after Dam overproduction and the ClpP protease then degrades LcrG, thereby releasing a block in type III secretion |
674306 |
| 2.1.1.72 | analysis |
structural model of the type IC M.EcoR124I DNA methyltransferase, comprising the HsdS subunit, two HsdM subunits, the cofactor S-adenosyl-L-methionine and the substrate DNA molecule |
676206 |
| 2.1.1.72 | analysis |
the dimer stabilizes and enhances site-specific DNA-binding by the MTase, because the DNA-binding site may require an interfacial structure formed by both monomers, role of Type II MTases as defense systems against phage |
676217 |
| 2.1.1.72 | analysis |
the first Gua is recognized by K9, removal of which abrogates the first base-pair recognition, the flipped target Ade binds to the surface of EcoDam in the absence of S-adenosyl-L-methionine, which illustrates a possible intermediate in the base-flipping pathway, the orphaned Thy residue displays structural flexibility by adopting an extrahelical or intrahelical position where it is in contact to N120 |
675380 |
| 2.1.1.72 | medicine |
confers antibiotic resistance in clinical isolates, important determinant of bacterial virulence, may be transmitted by horizontal gene transfer, potential drug target |
676752 |
| 2.1.1.72 | medicine |
Dam is essential for viability and mediates virulenc |
675828 |
| 2.1.1.72 | medicine |
DNA adenine methyltransferase identification is a useful technology to map holocarboxylase synthetase binding sites in human chromatin |
713742 |
| 2.1.1.72 | medicine |
epigenetic effects, in addition to genotoxic effects, need to be considered in chemical carcinogenesis initiated by r7,t8-dihydroxy-t9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, since the inhibition of methylation may allow the expression of genes that promote tumor development |
664054 |
| 2.1.1.72 | medicine |
essential for the viability of the bacterium, overproduction of Dam in Aeromonas hydrophila SSU reduces the virulence of the pathogen, decreases the motility and T3SS-associated cytotoxicity, but increases both the cytotoxicity and hemolysis associated with Act, mice infected with the Dam-overproducing strain do not die over a tested period of 3 weeks, indicating bacterial attenuation as a result of Dam overproduction |
-, 673988 |
