EC Number   |
Application |
Reference |
|---|
    2.1.1.45 | drug development |
the enzyme is a target for drug development in the treatement of Human African trypanosomiasis (HAT), an infectious disease caused by two distinct subspecies of the protozoan parasite Trypanosoma brucei subsp. gambiense and Trypanosoma brucei subsp. rhodesiense |
-, 743569 |
| 2.1.1.45 | medicine |
- |
-, 485361, 485375, 485386, 485387, 485389, 485391, 485400, 485403, 485404, 485413, 485415, 485419, 485426, 485430 |
| 2.1.1.45 | medicine |
development of antimalarial drugs, selective chemoptherapy directed at malarial TS, inhibitors of pyrimidine biosynthesis shall be considered for malaria chemotherapy |
485413 |
| 2.1.1.45 | medicine |
development of effective chemotherapy of the eosinophilic meningoencephalitis angiostrongylosis |
485404 |
| 2.1.1.45 | medicine |
drug development against cryptococcosis, a pulmonary subclinical infection, in immunocompromised individuals having diseases such as leukemia, lymphoma or AIDS the infection seminates to the central nervous system, the fourth most common opportunistic infection complicating AIDS |
-, 485403 |
| 2.1.1.45 | medicine |
enzyme is believed to be the major site of the cytotoxic action of the cancer chemotherapeutic drug 5-fluorouracil, development of inhibitors as clinical useful drugs |
485361, 485364, 485375, 485376, 485381, 485387, 485388, 485395, 485405, 485407, 485408, 485415, 485419, 485422, 485428, 485429, 485430, 485433 |
| 2.1.1.45 | medicine |
human TS mutants have potential applications in gene therapy by protecting hematopoietic progenitors from TS inhibitor toxicity, drug-resistant variants can be used to decrease the myelosuppressive side effects of TS-directed anticancer agents or to select genetically modified cells in vivo, clincal trials introduce chemoprotecting genes into hematopoietic cells |
485419, 485426, 485429 |
| 2.1.1.45 | medicine |
important drug target, fungus causes opportunistic pneumonia infections in immune-compromised patients and is among the leading causes of death of AIDS patients, inhibitors selective for fungal TS over human TS will be greatly beneficial in combating this disease |
485424 |
| 2.1.1.45 | medicine |
inhibition of human thymidylate synthase leads to apoptosis of rapidly dividing cells such as cancer cells, human thymidylate synthase is a target in the chemotherapy of colorectal cancer and some other neoplasms |
690892 |
| 2.1.1.45 | medicine |
inhibition of thymidylate synthase and DHFR enzymes has found clinical utility as antitumor, antimicrobial and antiprotozoal agents |
688294 |
