EC Number   |
Application |
Reference |
|---|
   1.3.99.5 | medicine |
enzyme isoform 2 gene variants are associated with sperm concentration and motility, but not with epidymal and accessory sex gland markers |
668960 |
| 1.3.99.5 | medicine |
in patients with hirsutism, positive correlation of enzyme isoforms 1 and 2 mRNA and concentration of free serum testosterone in dermal papillae from lower abdominal region |
668300 |
| 1.3.99.5 | medicine |
in recurrent prostate cancer, expression levels and isozyme activity shifts from isoform II towards isoform I. Immunostaining shows higher expression of isoform I than isoform II in recurrent prostate cancer, androgen-stimulated benign prostate, and in androgen-stimulated prostate cancers. Activity of isoform I is 3.7fold higher than isoform II in recurrent prostate cancers |
668281 |
| 1.3.99.5 | medicine |
inhibitor Strogen forte extract can be used for treatment of benign prostatic hyperplasia |
712201 |
| 1.3.99.5 | medicine |
therapeutic potential of enzyme inhibitors MK386 and MK906 to reduce growth and progression of prostatic cancer |
669566 |
| 1.3.99.5 | medicine |
treatment of patients with clinically localized prostate cancer with enzyme inhibitor dutasteride before radical prostatectomy. Treatment with dutasteride is associated with reductions in serum and intraprostatic dihydrotestosterone of more than 90%, and a decrease in total prostate and tumor volumes. No effect of dutasteride is noted on Gleason grade |
670738 |
| 1.3.99.5 | medicine |
two Korean sisters with male pseudohermaphroditism, showing a homozygous deletion of the thymine at nucleotide position c.655, leading to a frameshift mutation predicted to result in abnormally long protein with an extended termination signal |
668682 |
