EC Number   |
Application |
Reference |
|---|
    1.17.4.4 | medicine |
comparison of the effect of single nucleotide polymorphisms in African Americans and Caucasians. Subjects carrying an 1173T allele have a lower warfarin maintenance compared with subjects with the CC genotype in African americans and Caucasians. Before reaching maintenance dose, only Caucasians with the T allele have significantly increased risk of international normlized ratio > 3 compared with Caucasians with the CC genotype. Polymorphisms may not be useful in predicting over-coagulation among African Americans |
686190 |
| 1.17.4.4 | medicine |
patient with warfarin resistance due to a T383G transition in exon 2 of the VKORC1 gene, patient is heterozygous for the mutation |
687208 |
| 1.17.4.4 | medicine |
polymorphisms in the VKORC1 gene are important determinants of warfarin dose requirements in Turkish patients |
697715 |
| 1.17.4.4 | medicine |
study on the association between the 1173C>T polymorphism in the VKORC1 gene and calcification of the aortic far wall. Persons with at least one T-allele have a statistically significant 19% risk increase of calcification of the aortic far wall compared to CC homozygous persons, adjusted for age and gender |
684790 |
| 1.17.4.4 | medicine |
the determination of VKORC1-3 and VKORC1-4 haplotypes may be an important addition to CYP2C9 and VKORC1-2 genotyping to identify patients at risk of being outside the target range during initial anticoagulation with acenocoumarol |
700608 |
| 1.17.4.4 | medicine |
the enzyme is regulated by microRNA miR-133a, which may have potential importance for anticoagulant therapy or aortic calcification |
725987 |
| 1.17.4.4 | medicine |
the enzyme is the therapeutic target site for warfarin, an anticoagulant that is prescribed widely for the treatment and prevention of thrombosis. Point mutations in VKORC1 may be an important, though rare, cause of warfarin resistance in anticoagulation clinic populations |
657387 |
| 1.17.4.4 | medicine |
the single nucleotide polymorphism G1639A is a suitable biomarker for warfarin dosing across ethnic populations. Preferential association of the promoter -1639 G allele with active chromatin |
685791 |
| 1.17.4.4 | medicine |
the T-allele of the VKORC1 1173CT polymorphism is associated with a significantly higher risk of aortic calcification in Whites |
744186 |
| 1.17.4.4 | medicine |
vitamin K 2,3-epoxide reductase complex subunit 1 is is the target of oral anticoagulant drugs and a relevant molecule for cardiovascular diseases |
725987 |
