EC Number   |
Application |
Reference |
|---|
    1.14.15.4 | analysis |
use of primary culture of hippocampal neurons isolated from fetus as a model system to study the regulation of the enzymes responsible for corticoid synthesis |
659746 |
| 1.14.15.4 | drug development |
the enzyme is a target for development of selective and potent CYP11B2 inhibitors |
725981 |
| 1.14.15.4 | medicine |
blocking of aldosterone synthesis by mediating aldosterone synthase activity is a possible pharmacological therapy for hypertension |
725981 |
| 1.14.15.4 | medicine |
increased sensitivity of adrenocortical stereoidgenesis to adrenocorticotropic hormone in Milan hypertensive rats, enzyme is not affected |
657511 |
| 1.14.15.4 | medicine |
inhibitors for P-45011beta, against aldosterone overproduction which leads to oedematous diseases and hypertension |
285402, 285403, 285404 |
| 1.14.15.4 | medicine |
treatment of hyperaldosteronism, congestive heart failure, and myocardial fibrosis by lowering the elevated plasma aldosterone levels via blockade of aldosterone synthase, CYP11B2, the key enzyme of mineralocorticoid biosynthesis |
712715 |
| 1.14.15.4 | more |
assays can be used for assessing the potency and selectivity of CYP11B2 inhibitors for the treatment of hypertension and heart failure |
695555 |
