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1.1.1.244
biotechnology
metabolic engineering of Escherichia coli for high yield production of succinic acid driven by methanol. When methanol assimilation module is introduced into succinic acid producing Escherichia coli by employing the NAD-dependent methanol dehydrogenase from Bacillus methanolicus and ribulose monophosphate pathway from different donor organisms, succinic acid yield is increased from 0.91 g/g to 0.98 g/g with methanol as an auxiliary substrate under the anaerobic fermentation
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