EC Number   |
Application |
Reference |
|---|
    1.1.1.22 | agriculture |
changes in the mRNA level during peach fruit development correspond to changes in the amount of cell wall material and the cell wall uronic acid content. These are greater in the fruits of the commercial cultivars compared with the Japanese native peach cultivars, and the expression of enzyme is higher in the fruits of the commercial cultivars |
726483 |
| 1.1.1.22 | medicine |
biallelic mutations in UGDH cause developmental epileptic encephalopathy. In 36 cases from 25 families presenting with epileptic encephalopathy with developmental delay and hypotonia, mutations either impair UGDH stability, oligomerization, or enzymatic activity. In vitro, patient-derived cerebral organoids are smaller with a reduced number of proliferating neuronal progenitors |
761985 |
| 1.1.1.22 | medicine |
epirubicin accumulation increases and apoptosis decreases during UGDH knockdown. Hyaluronan-coated matrix increases and a positive modulation of autophagy is detected. Higher levels of UGDH are correlated with worse prognosis in triple-negative breast cancer patients that receive chemotherapy. High expression of UGDH is found in tumoral tissue from HER2--patients. UGDH knockdown contributes to epirubicin resistance |
760676 |
| 1.1.1.22 | medicine |
expression of UDP-glucose dehydrogenase is up-regulated in highly metastatic ovarian cancer TOV-21G cells, but not in normal adjacent tissue. RNAi-mediated silencing results in a significant decrease in metastatic ability in transwell migration, transwell invasion and wound healing assays. The knockdown of UGDH causes cell cycle arrest in the G0/G1 phase and induces a massive decrease of tumour formation rate in vivo. UGDH-depletion leads to the down-regulation of epithelial-mesenchymal transition-related markers as well as MMP2, and inactivation of the ERK/MAPK pathway |
761588 |
| 1.1.1.22 | medicine |
high UGDH expression is associated with decreased patient survival in poor-prognosis breast cancer subsets |
760809 |
| 1.1.1.22 | medicine |
knocking out UGDH in highly metastatic 6DT-1 breast cancer cells impairs migration ability without affecting in vitro proliferation. UGDH-KO results in significantly decreased metastatic capacity in vivo when the cells are orthotopically injected in syngeneic mice |
760809 |
| 1.1.1.22 | medicine |
manipulation of UGDH activity by hexamer stabilization may offer therapeutic options in cancer and other pathologies |
740715 |
| 1.1.1.22 | medicine |
possibility that gallic acid and quercetin may modulate human breast cancer cell proliferation by inhibiting UGDH |
697937 |
| 1.1.1.22 | medicine |
shRNA-mediated knockdown of UGDH inhibits breast cancer invasion, colony formation, and tumor growth |
762065 |
| 1.1.1.22 | medicine |
UGDH content in prostatic acini is a novel candidate biomarker that may complement the development of a multi-biomarker panel for detecting prostate cancer within the tumor adjacent field on a histologically normal biopsy specimen |
698331 |
