aluminium chloride
activates the enzyme in vitro and in vivo after oral treatment
ammonium sulfate
activates optimally at 0.2 M
Ca2+
activates isozymes AChEA and AChEB
Ca2+
activation above 1 mM
Ca2+
divalent metal ion required
Co2+
activates isozymes AChEA and AChEB
Iron
in vitro, iron promotes a significant increase in AChE activity in brain (52%) and liver (53%) at the higher concentration (2.6 mM). In vivo, a significant increase in enzyme activity is observed in the presence of 15 mg/l in both, brain (62%) and liver tissue (70%)
Mg2+
activation above 1 mM
Mg2+
ameliorates inhibitory effects of AChE inhibitors
Mg2+
divalent metal ion required, highest activity