3.1.1.7 1,1-dimethyl-4-acetylthiomethylpiperidinium + H2O i.e. MATP+, paper spray mass spectrometry is used to monitor the activity of acetylcholinesterase, both in-solution and on modified hydrophobic paper surface. Hydrophobic paper surfaces are prepared using vaporized trichloro(3,3,3-trifluoropropyl)silane. In both approaches, mixtures of diluted human whole blood with and without inhibitor ethyl ((2-[bis(propan-2-yl)amino]ethyl)sulfanyl)(methyl)phosphonate (VX) are mixed with a non-endogenous AChE specific substrate, 1,1-dimethyl-4-acetylthiomethylpiperidinium (MATP+). Formation of the cleaved MATP+ product is monitored over time and compared to MATP+ to determine relative AChE activity. This on-substrate assay is effective at determining AChE activity and identifying the toxicant, while determination of AChE activity in-solution proceeds at a slower rate. Method evaluation, overview Homo sapiens ? - ? 446522 3.1.1.7 1-naphthyl acetate + H2O a chromogenic substrate for detection of erythrocyte acetylcholinesterase activity Homo sapiens 1-naphthol + acetate - ? 12515 3.1.1.7 2,6-dichloro-3'-methylindophenylacetate + H2O - Neptunea eulimata 2,6-dichloro-3'-methylindophenol + acetate - ? 364393 3.1.1.7 2,6-dichloro-3'-methylindophenylacetate + H2O weak substrate Homo sapiens 2,6-dichloro-3'-methylindophenol + acetate - ? 364393 3.1.1.7 2,6-dichlorophenolindophenol acetate + H2O 2,6-dichlorophenolindophenol acetate computational molecular docking study using the enzyme's crystal structure, PDB ID 4YE7 Homo sapiens 2,6-dichlorophenolindophenol + acetate - ? 446624 3.1.1.7 2,6-dichlorophenolindophenylacetate + H2O - Homo sapiens 2,6-dichlorophenolindophenol + acetate - ? 364391 3.1.1.7 2,6-dichlorophenolindophenylacetate + H2O - Neptunea eulimata 2,6-dichlorophenolindophenol + acetate - ? 364391 3.1.1.7 2-methoxyacetylthiocholine + H2O recombinant enzyme shows about 12% activity compared to acetylthiocholine Homo sapiens thiocholine + 2-methoxyacetate - ? 416140 3.1.1.7 2-methoxyacetylthiocholine + H2O recombinant enzyme shows about 65% activity compared to acetylthiocholine Lucilia cuprina thiocholine + 2-methoxyacetate - ? 416140 3.1.1.7 3',5'-dichloro-2'-methylindophenylacetate + H2O weak substrate Homo sapiens 3',5'-dichloro-2'-methylindophenol + acetate - ? 364394 3.1.1.7 3',5'-dichlorophenolindophenylacetate + H2O weak substrate Homo sapiens 3',5'-dichlorophenolindophenol + acetate - ? 364392 3.1.1.7 3-(acetamido)-N,N,N-trimethylanilinium + H2O slow hydrolysis Homo sapiens ? - ? 416219 3.1.1.7 3-(acetamido)-N,N,N-trimethylanilinum + H2O ATMA Homo sapiens ? - ? 364389 3.1.1.7 3-methylbutyrylthiocholine + H2O recombinant enzyme shows about 1% activity compared to acetylthiocholine Homo sapiens thiocholine + 3-methylbutyrate - ? 416241 3.1.1.7 3-methylbutyrylthiocholine + H2O recombinant enzyme shows less than 1% activity compared to acetylthiocholine Lucilia cuprina thiocholine + 3-methylbutyrate - ? 416241 3.1.1.7 6-monoacetylmorphine + H2O - Homo sapiens morphine + acetate - ? 115471 3.1.1.7 acetyl(beta-methyl)thiocholine iodide + H2O - Schizaphis graminum 1-methyl(thio)choline iodide + acetate - ? 416492 3.1.1.7 acetyl-(beta-methyl)thiocholine + H2O - Schizaphis graminum (beta-methyl)thiocholine + acetate - ? 364395 3.1.1.7 acetyl-(beta-methyl)thiocholine iodide + H2O - Anopheles gambiae acetate + methylthiocholine iodide - ? 411546 3.1.1.7 acetyl-beta-methyl-thiocholine + H2O - Mytilus edulis beta-methyl-thiocholine + acetate - ? 364361 3.1.1.7 acetyl-beta-methylcholine + H2O - Homo sapiens methylcholine + acetate - ? 364373 3.1.1.7 acetyl-beta-methylcholine + H2O - Todarodes pacificus beta-methylcholine + acetate - ? 446919 3.1.1.7 acetyl-beta-methylcholine + H2O - Berryteuthis magister beta-methylcholine + acetate - ? 446919 3.1.1.7 acetyl-beta-methylthiocholine + H2O - Homo sapiens beta-methylthiocholine + acetate - ? 364397 3.1.1.7 acetyl-beta-methylthiocholine + H2O - Mytilus galloprovincialis beta-methylthiocholine + acetate - ? 364397 3.1.1.7 acetyl-beta-methylthiocholine + H2O - Perforatus perforatus beta-methylthiocholine + acetate - ? 364397 3.1.1.7 acetyl-beta-methylthiocholine + H2O preferred substrate Pollicipes pollicipes beta-methylthiocholine + acetate - ? 364397 3.1.1.7 acetyl-beta-methylthiocholine + H2O - Palaemon serratus ? + acetate - ? 381319 3.1.1.7 acetyl-homo-thiocholine + H2O recombinant enzyme shows less than 10% activity compared to acetylthiocholine Homo sapiens ? - ? 416496 3.1.1.7 acetyl-homo-thiocholine + H2O recombinant enzyme shows less than 10% activity compared to acetylthiocholine Lucilia cuprina ? - ? 416496 3.1.1.7 acetyl-[beta-methyl]thiocholine + H2O - Nippostrongylus brasiliensis acetate + [beta-methyl]thiocholine - ? 83077 3.1.1.7 acetyl-[beta-methyl]thiocholine + H2O - Rhyzopertha dominica acetate + [beta-methyl]thiocholine - ? 83077 3.1.1.7 acetylcholine + H2O - Mus musculus acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Homo sapiens acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Rattus norvegicus acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Bos taurus acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Aedes aegypti acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Electrophorus electricus acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Cimex lectularius acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Anopheles gambiae acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Periplaneta americana acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Culex pipiens acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Blattella germanica acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Tribolium confusum acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Harmonia axyridis acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Vespula maculifrons acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline Electrophorus electricus acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion Mus musculus acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion Homo sapiens acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Cimex lectularius Bedbug acetate + choline - ? 73377 3.1.1.7 acetylcholine + H2O - Gallus gallus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Cavia porcellus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Drosophila melanogaster choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Mus musculus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Homo sapiens choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Rattus norvegicus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Sus scrofa choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Bos taurus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Oryctolagus cuniculus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Ovis aries choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Pisum sativum choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Apis mellifera choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Schistosoma mansoni choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Macaca mulatta choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Oncorhynchus mykiss choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Todarodes pacificus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Musca domestica choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Ciona intestinalis choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Mytilus galloprovincialis choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Sitophilus oryzae choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Bungarus multicinctus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Electrophorus electricus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Torpedo sp. choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Eledone moschata choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Polysphondylium violaceum choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Narke japonica choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Danio rerio choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Cimex lectularius choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Sparus aurata choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Aphis gossypii choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Neptunea eulimata choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Schizaphis graminum choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Trypanosoma evansi choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Pseudorasbora parva choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Bactrocera dorsalis choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Carassius auratus auratus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Liposcelis entomophila choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Berryteuthis magister choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Heterorhabditis bacteriophora choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Uria aalge choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Fratercula arctica choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Alca torda choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Dugesia japonica choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Tetronarce californica choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Crassostrea hongkongensis choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Rhopalosiphum padi choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Sitobion avenae choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Oomyzus sokolowskii choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Cichla ocellaris choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Pardosa pseudoannulata choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Tetranychus urticae choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Lepeophtheirus salmonis choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Aphis citricidus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Periplaneta americana choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Plutella xylostella choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Parachromis managuensis choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Pollicipes pollicipes choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Hoplosternum littorale choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Perforatus perforatus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Gambusia yucatana choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O preferred substrate Perforatus perforatus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O esteratic and anionic subsites act together to achieve substrate binding specificity Mus musculus choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O key enzyme in the central and peripheral nervous systems where it is responsible for the hydrolysis of neurotransmitter acetylcholine into choline and acetate Homo sapiens choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview Homo sapiens choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O substrate traffic in AChE involves at least two binding sites, the catalytic and peripheral anionic sites, which are allosterically related and involved in substrate inhibition, structure-function relationship analysis, overview Tetronarce californica choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O fast hydrolysis Homo sapiens choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Heterorhabditis bacteriophora EM2 choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Rattus norvegicus Wistar choline + acetate - ? 83074 3.1.1.7 acetylcholine + H2O - Drosophila melanogaster ? - ? 369713 3.1.1.7 acetylcholine + H2O - Musca domestica ? - ? 369713 3.1.1.7 acetylcholine + H2O - Eledone moschata ? - ? 369713 3.1.1.7 acetylcholine + H2O inactivation of transmitter substance operating in cholinergic neurotransmission Gallus gallus ? - ? 369713 3.1.1.7 acetylcholine + H2O inactivation of transmitter substance operating in cholinergic neurotransmission Rattus norvegicus ? - ? 369713 3.1.1.7 acetylcholine + H2O inactivation of transmitter substance operating in cholinergic neurotransmission Bos taurus ? - ? 369713 3.1.1.7 acetylcholine + H2O inactivation of transmitter substance operating in cholinergic neurotransmission Ovis aries ? - ? 369713 3.1.1.7 acetylcholine + H2O inactivation of transmitter substance operating in cholinergic neurotransmission Myxine glutinosa ? - ? 369713 3.1.1.7 acetylcholine + H2O inactivation of transmitter substance operating in cholinergic neurotransmission Torpedo sp. ? - ? 369713 3.1.1.7 acetylcholine + H2O inactivation of transmitter substance operating in cholinergic neurotransmission Walterinnesia aegyptia ? - ? 369713 3.1.1.7 acetylcholine + H2O inactivation of transmitter substance operating in cholinergic neurotransmission Rhyzopertha dominica ? - ? 369713 3.1.1.7 acetylcholine + H2O synaptic transmission, termination of impulse transmission at cholinergic synapses by hydrolysis Torpedo sp. ? - ? 369713 3.1.1.7 acetylcholine + H2O - Drosophila melanogaster MH19 ? - ? 369713 3.1.1.7 acetylcholine chloride + H2O - Macroptilium atropurpureum choline chloride + acetate - ? 390165 3.1.1.7 acetylcholine chloride + H2O - Electrophorus electricus acetate + choline chloride - ? 411565 3.1.1.7 acetylcholine iodide + H2O - Gallus gallus acetate + choline iodide - ? 83076 3.1.1.7 acetylcholine iodide + H2O - Mus musculus acetate + choline iodide - ? 83076 3.1.1.7 acetylcholine iodide + H2O - Rattus norvegicus acetate + choline iodide - ? 83076 3.1.1.7 acetylcholine iodide + H2O - Bos taurus acetate + choline iodide - ? 83076 3.1.1.7 acetylcholine iodide + H2O - Haemonchus contortus acetate + choline iodide - ? 83076 3.1.1.7 acetylcholine iodide + H2O - Trichostrongylus colubriformis acetate + choline iodide - ? 83076 3.1.1.7 acetylcholine iodide + H2O - Walterinnesia aegyptia acetate + choline iodide - ? 83076 3.1.1.7 acetylcholine iodide + H2O - Gallotia galloti acetate + choline iodide - ? 83076 3.1.1.7 acetylcholine iodide + H2O - Gammarus pulex acetate + choline iodide - ? 83076 3.1.1.7 acetylthiocholine + H2O - Mus musculus acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Homo sapiens acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Rattus norvegicus acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Sus scrofa acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Bos taurus acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Zea mays acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Oreochromis niloticus acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Electrophorus electricus acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Tetronarce californica acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O detection using 5,5'-dithiobis(2-nitrobenzoic acid) Homo sapiens acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O most efficiently hydrolyzed substrate Oreochromis niloticus acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O most efficiently hydrolyzed substrate Colossoma macropomum acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O most efficiently hydrolyzed substrate Rachycentron canadum acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O most efficiently hydrolyzed substrate Arapaima gigas acetate + thiocholine - ? 73373 3.1.1.7 acetylthiocholine + H2O - Gallus gallus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Cavia porcellus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Drosophila melanogaster thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Mus musculus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Homo sapiens thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Rattus norvegicus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Sus scrofa thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Bos taurus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Oryctolagus cuniculus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Ovis aries thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Pisum sativum thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Nippostrongylus brasiliensis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Todarodes pacificus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Myxine glutinosa thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Tetronarce californica thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Sitophilus oryzae thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Electrophorus electricus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Eledone moschata thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Rhyzopertha dominica thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Dendrobaena veneta thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Danio rerio thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Bungarus fasciatus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Macaca mulatta thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Schizaphis graminum thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Trypanosoma evansi thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Lytechinus variegatus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Locusta migratoria manilensis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Bactrocera dorsalis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Schistosoma mansoni thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Schistosoma haematobium thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Schistosoma bovis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Gambusia holbrooki thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Nephotettix cincticeps Uhler thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Berryteuthis magister thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Heterorhabditis bacteriophora thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Eisenia andrei thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Colossoma macropomum thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Ctenocephalides felis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Stomoxys calcitrans thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Crassostrea hongkongensis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Rhopalosiphum padi thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Sitobion avenae thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Oomyzus sokolowskii thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Pardosa pseudoannulata thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Aphis citricidus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Periplaneta americana thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Plutella xylostella thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Parachromis managuensis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Pollicipes pollicipes thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Hoplosternum littorale thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Gambusia yucatana thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O best substrate Homo sapiens thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O best substrate Rattus norvegicus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O best substrate Mytilus edulis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O best substrate Mytilus galloprovincialis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O best substrate Locusta migratoria manilensis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O preferred substrate Mytilus galloprovincialis thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O preferred substrate Palaemon serratus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O preferred substrate Perforatus perforatus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O acetylthiocholine iodide Diopatra neapolitana thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O 100% activity Homo sapiens thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O 100% activity Lucilia cuprina thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O catalytic residues are Ser200 and Trp84 Tetronarce californica thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O fast hydrolysis Homo sapiens thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O isoform AChE2 has approximately 2500fold greater catalytic efficiency toward acetylthiocholine and butyrylthiocholine than isoform AChE1 Apis mellifera thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O activity of AChE is determined by Ellman's method using acetylthiocholine iodide as a substrate Homo sapiens thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O activity of AChE is determined by Ellman's method using acetylthiocholine iodide as a substrate Rattus norvegicus thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O best substrate for both isozymes AChEA and AChEB Heterorhabditis bacteriophora thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O i.e. acetyl-beta-(methyl)thiocholine iodide (AbMSCh) as substrate Sparus aurata thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O preferred substrate, isozyme PpAChE5 shows the highest catalytic efficiency (Vmax/KM) for substrate acetylthiocholine, which is about 5.4 and 8.6 times compared to butyrylthiocholine and propionylthiocholine, respectively Pardosa pseudoannulata thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O substrate is acetylthiocholine iodide Homo sapiens thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O substrate is acetylthiocholine iodide, activity detection using 5,5'-dithio-bis(2-nitrobenzoic acid) colorimetric assay and measurement of the absorbance at 412 nm Tetronarce californica thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O substrate is acetylthiocholine iodide, activity detection using 5,5'-dithio-bis(2-nitrobenzoic acid) colorimetric assay and measurement of the absorbance at 412 nm Homo sapiens thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O - Heterorhabditis bacteriophora EM2 thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine + H2O activity of AChE is determined by Ellman's method using acetylthiocholine iodide as a substrate Rattus norvegicus Wistar thiocholine + acetate - ? 83075 3.1.1.7 acetylthiocholine chloride + H2O - Macroptilium atropurpureum thiocholine chloride + acetate - ? 391173 3.1.1.7 acetylthiocholine chloride + H2O - Homo sapiens acetate + thiocholine chloride - ? 411567 3.1.1.7 acetylthiocholine iodide + H2O - Homo sapiens acetate + thiocholine iodide - ? 364360 3.1.1.7 acetylthiocholine iodide + H2O - Rattus norvegicus acetate + thiocholine iodide - ? 364360 3.1.1.7 acetylthiocholine iodide + H2O - Anopheles gambiae acetate + thiocholine iodide - ? 364360 3.1.1.7 acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens acetate + thiocholine iodide - ? 364360 3.1.1.7 acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Rattus norvegicus acetate + thiocholine iodide - ? 364360 3.1.1.7 acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Electrophorus electricus acetate + thiocholine iodide - ? 364360 3.1.1.7 acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Drosophila melanogaster acetate + thiocholine iodide - ? 364360 3.1.1.7 acetylthiocholine iodide + H2O - Mus musculus thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Homo sapiens thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Rattus norvegicus thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Oryctolagus cuniculus thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Musca domestica thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Blattella germanica thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Schizaphis graminum thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Eisenia andrei thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Tetronarce californica thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O preferred substrate Heterorhabditis bacteriophora thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O highly preferred substrate Gammarus pulex thiocholine iodide + acetate - ? 364386 3.1.1.7 acetylthiocholine iodide + H2O - Homo sapiens thiocholine + acetate - ? 391174 3.1.1.7 acetylthiocholine iodide + H2O - Cichla ocellaris thiocholine + acetate - ? 391174 3.1.1.7 alkyl methylphosphonfluoridate + H2O oxime-assisted catalysis of organophosphates by AChE, mechanism, reaction system, overview Mus musculus ? - ? 391217 3.1.1.7 alpha-naphthyl acetate + H2O - Homo sapiens alpha-naphthol + acetate - ? 36052 3.1.1.7 alpha-naphthyl acetate + H2O - Liposcelis bostrychophila alpha-naphthol + acetate - ? 36052 3.1.1.7 alpha-naphthyl acetate + H2O - Liposcelis entomophila alpha-naphthol + acetate - ? 36052 3.1.1.7 alpha-naphthyl acetate + H2O - Electrophorus electricus 1-naphthol + acetate - ? 73361 3.1.1.7 aryl-acyl-amides + H2O - Gallus gallus ? - ? 83168 3.1.1.7 aryl-acyl-amides + H2O - Rattus norvegicus ? - ? 83168 3.1.1.7 aryl-acyl-amides + H2O - Bos taurus ? - ? 83168 3.1.1.7 aryl-acyl-amides + H2O - Torpedo sp. ? - ? 83168 3.1.1.7 benzoylthiocholine + H2O recombinant enzyme shows about 1% activity compared to acetylthiocholine Homo sapiens thiocholine + benzoate - ? 364409 3.1.1.7 benzoylthiocholine + H2O recombinant enzyme shows about 1% activity compared to acetylthiocholine Lucilia cuprina thiocholine + benzoate - ? 364409 3.1.1.7 benzoylthiocholine + H2O 13% and 9% activity compared to acetylthiocholine with isozymes AChEA and AChEB, respectively Heterorhabditis bacteriophora thiocholine + benzoate - ? 364409 3.1.1.7 benzoylthiocholine iodide + H2O 22.2% activity compared to acetylthiocholine Heterorhabditis bacteriophora thiocholine iodide + benzoate - ? 391424 3.1.1.7 butylthiocholine + H2O - Rhopalosiphum padi thiocholine + butanol - ? 430009 3.1.1.7 butylthiocholine + H2O - Sitobion avenae thiocholine + butanol - ? 430009 3.1.1.7 butyryl choline + H2O - Coturnix coturnix butyrate + choline - ? 364410 3.1.1.7 butyrylthiocholine + H2O - Gallus gallus butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Bos taurus butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Pisum sativum butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Nippostrongylus brasiliensis butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Myxine glutinosa butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Oreochromis niloticus butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Eledone moschata butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Rhyzopertha dominica butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Schistosoma mansoni butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Schistosoma haematobium butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Schistosoma bovis butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Nephotettix cincticeps Uhler butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Colossoma macropomum butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Rachycentron canadum butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Arapaima gigas butyrate + thiocholine - ? 83078 3.1.1.7 butyrylthiocholine + H2O - Mus musculus thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Homo sapiens thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Mytilus edulis thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Oreochromis niloticus thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Lytechinus variegatus thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Ctenocephalides felis thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Stomoxys calcitrans thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Pardosa pseudoannulata thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Aphis citricidus thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O very low activity Mytilus galloprovincialis thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O low activity Perforatus perforatus thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O worst substrate Locusta migratoria manilensis thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O lower activity Pardosa pseudoannulata thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O native enzyme shows about 50% activity and recombinant enzyme shows about 45% activity compared to acetylthiocholine Lucilia cuprina thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O recombinant enzyme shows about 3% activity compared to acetylthiocholine Homo sapiens thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O isoform AChE2 has approximately 2500fold greater catalytic efficiency toward acetylthiocholine and butyrylthiocholine than isoform AChE1 Apis mellifera thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O 48% and 41% activity compared to acetylthiocholine with isozymes AChEA and AChEB, respectively Heterorhabditis bacteriophora thiocholine + butyrate - ? 364362 3.1.1.7 butyrylthiocholine + H2O - Locusta migratoria manilensis thiocholine + butanoate - ? 381607 3.1.1.7 butyrylthiocholine + H2O - Palaemon serratus thiocholine + butanoate very bad substrate ? 381607 3.1.1.7 butyrylthiocholine iodide + H2O - Blattella germanica thiocholine iodide + butyrate - ? 364398 3.1.1.7 butyrylthiocholine iodide + H2O - Eisenia andrei thiocholine iodide + butyrate - ? 364398 3.1.1.7 butyrylthiocholine iodide + H2O - Cyprinus carpio thiocholine iodide + butyrate - ? 364398 3.1.1.7 butyrylthiocholine iodide + H2O low activity Gammarus pulex thiocholine iodide + butyrate - ? 364398 3.1.1.7 butyrylthiocholine iodide + H2O 41.7% activity compared to acetylthiocholine Heterorhabditis bacteriophora thiocholine iodide + butyrate - ? 364398 3.1.1.7 carbachol + H2O slow hydrolysis Homo sapiens ? - ? 416747 3.1.1.7 cyclopentylcarbonylthiocholine + H2O recombinant enzyme shows about 4% activity compared to acetylthiocholine Homo sapiens thiocholine + cyclopentanecarboxylate - ? 416806 3.1.1.7 cyclopentylcarbonylthiocholine + H2O recombinant enzyme shows less than 1% activity compared to acetylthiocholine Lucilia cuprina thiocholine + cyclopentanecarboxylate - ? 416806 3.1.1.7 cyclopropylcarbonylthiocholine + H2O recombinant enzyme shows about 4% activity compared to acetylthiocholine Homo sapiens thiocholine + cyclopropanecarboxylate - ? 416808 3.1.1.7 cyclopropylcarbonylthiocholine + H2O recombinant enzyme shows about 5% activity compared to acetylthiocholine Lucilia cuprina thiocholine + cyclopropanecarboxylate - ? 416808 3.1.1.7 diisopropyl phosphofluoridate + H2O mutant G117H, no activity with the wild-type enzyme Homo sapiens ? - ? 391837 3.1.1.7 diisopropyl phosphofluoridate + H2O mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme Bungarus fasciatus ? - ? 391837 3.1.1.7 echothiophate + H2O mutant G117H, no activity with the wild-type enzyme Homo sapiens ? - ? 391899 3.1.1.7 echothiophate + H2O mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme Bungarus fasciatus ? - ? 391899 3.1.1.7 edrophonium chloride + H2O - Electrophorus electricus ? - ? 391901 3.1.1.7 heroin + H2O - Homo sapiens 6-monoacetylmorphine + acetate - ? 115470 3.1.1.7 hexanoylthiocholine + H2O recombinant enzyme shows about 6% activity compared to acetylthiocholine Homo sapiens thiocholine + hexanoate - ? 417092 3.1.1.7 hexanoylthiocholine + H2O recombinant enzyme shows less than 1% activity compared to acetylthiocholine Lucilia cuprina thiocholine + hexanoate - ? 417092 3.1.1.7 indophenylacetate + H2O - Homo sapiens indophenol + acetate - ? 364390 3.1.1.7 indophenylacetate + H2O - Neptunea eulimata indophenol + acetate - ? 364390 3.1.1.7 isobutyrylthiocholine + H2O recombinant enzyme shows about 15% activity compared to acetylthiocholine Lucilia cuprina thiocholine + isobutyrate - ? 417112 3.1.1.7 isobutyrylthiocholine + H2O recombinant enzyme shows about 2% activity compared to acetylthiocholine Homo sapiens thiocholine + isobutyrate - ? 417112 3.1.1.7 Leu + Arg - Bos taurus Tyr + Gly - ? 83083 3.1.1.7 Leu + Met - Bos taurus substance P - ? 83085 3.1.1.7 methylthiocholine + H2O - Rhopalosiphum padi thiocholine + methanol - ? 430420 3.1.1.7 methylthiocholine + H2O - Sitobion avenae thiocholine + methanol - ? 430420 3.1.1.7 additional information - Gallus gallus ? - ? 89 3.1.1.7 additional information - Homo sapiens ? - ? 89 3.1.1.7 additional information - Rattus norvegicus ? - ? 89 3.1.1.7 additional information - Bos taurus ? - ? 89 3.1.1.7 additional information - Torpedo sp. ? - ? 89 3.1.1.7 additional information acts on a variety of acetic acid esters, also catalyzes transacetylation Schistosoma mansoni ? - ? 89 3.1.1.7 additional information not: beta-endorphin, angiotensin, oxytoxin, vasopressin Bos taurus ? - ? 89 3.1.1.7 additional information complex with fasciculin-2 exhibits hydrolytic activity in a buryrylcholinesterase-like kinetics, the switch appears to be a consequence of steric obstruction, but also the consequence of subtle rapid conformational changes around the catalytic site Electrophorus electricus ? - ? 89 3.1.1.7 additional information pivotal role in the cholinergic system, rapid termination of nerve impulse transmission Homo sapiens ? - ? 89 3.1.1.7 additional information pivotal role in the cholinergic system, rapid termination of nerve impulse transmission Bos taurus ? - ? 89 3.1.1.7 additional information pivotal role in the cholinergic system, rapid termination of nerve impulse transmission Macaca mulatta ? - ? 89 3.1.1.7 additional information no substrate: S-butyrylthiocholine Zea mays ? - ? 89 3.1.1.7 additional information calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview Homo sapiens ? - ? 89 3.1.1.7 additional information the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues Mus musculus ? - ? 89 3.1.1.7 additional information the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview Cavia porcellus ? - ? 89 3.1.1.7 additional information the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview Homo sapiens ? - ? 89 3.1.1.7 additional information lethal effects due to enzyme inhibition in vivo appear at inhibition levels over 50% Gammarus pulex ? - ? 89 3.1.1.7 additional information substrate and product trafficking through the active center gorge of the enzyme analyzed by crystallography and equilibrium binding, binding structures, overview Mus musculus ? - ? 89 3.1.1.7 additional information acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission Homo sapiens ? - ? 89 3.1.1.7 additional information AChE is an acetylcholine-hydrolyzing enzyme and is implicated in cognitive functions and probably plays important roles in neurodegenerative disorders, including Alzheimer's disease Rattus norvegicus ? - ? 89 3.1.1.7 additional information brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview Mus musculus ? - ? 89 3.1.1.7 additional information inhibition of AChE, along with the butyrylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia Homo sapiens ? - ? 89 3.1.1.7 additional information presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview Mus musculus ? - ? 89 3.1.1.7 additional information active site structure and substrate channels of wild-type and mutant enzymes, overview Drosophila melanogaster ? - ? 89 3.1.1.7 additional information Checx1, Checx2, and Checx3 are three carboxylesterases, that perform the acetylcholineesterase reaction, overview Clytia hemisphaerica ? - ? 89 3.1.1.7 additional information development of an assay method for quantification of the product of enzymatic reaction using substrate as internal standard, thus eliminating the need for addition of an internal standard, mass spectrometric analysis, overview Electrophorus electricus ? - ? 89 3.1.1.7 additional information the catalytic triad is formed by His440, Glu327, and Ser200, Trp84 and Trp279 are important for the enzyme activity Tetronarce californica ? - ? 89 3.1.1.7 additional information AChE1 is also activity with propionylthiocholine iodide and butyrylthiocholine iodide Anopheles gambiae ? - ? 89 3.1.1.7 additional information activity detection using a capillary electrophoresis, EMMA, method, screening method development and optimization of experimental conditions, overview Electrophorus electricus ? - ? 89 3.1.1.7 additional information bioassay for inhibition of fibril formation, i.e. Thioflavin T assay Homo sapiens ? - ? 89 3.1.1.7 additional information the ensemble of compound 1 and compound 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview Homo sapiens ? - ? 89 3.1.1.7 additional information isoform AChE1 is the dominant activity in Ctenocephalides felis imagoes Ctenocephalides felis ? - ? 89 3.1.1.7 additional information acetylcholinesterase also shows activity with butyrylthiocholine, butyrylcholine, and propionylthiocholine, cf. EC 3.1.1.8 Todarodes pacificus ? - ? 89 3.1.1.7 additional information acetylcholinesterase also shows activity with butyrylthiocholine, butyrylcholine, and propionylthiocholine, cf. EC 3.1.1.8 Berryteuthis magister ? - ? 89 3.1.1.7 additional information activity detection with chromogenic reagent 5,5'-dithiobis-(2-nitrobenzoic) acid (DTNB) Hoplosternum littorale ? - ? 89 3.1.1.7 additional information all substrate are used as iodides Heterorhabditis bacteriophora ? - ? 89 3.1.1.7 additional information interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators, analysis of reactivation and inhibition kinetics in vitro, overview Homo sapiens ? - ? 89 3.1.1.7 additional information Mytilus galloprovincialis ChE degrades preferentially acetylthiocholine (AcSCh), followed by acetyl-beta-methylthiocholine (AbSCh) and propionylthiocholine (PrSCh), while butyrylthiocholine (BuSCh) is poorly hydrolysed. About 9% to 10% of the ChE activity observed, with AcSCh as substrate, is probably due to other esterases (CoEs) activity Mytilus galloprovincialis ? - ? 89 3.1.1.7 additional information no activity with butyrylcholine Homo sapiens ? - ? 89 3.1.1.7 additional information no activity with butyrylthiocholine Sparus aurata ? - ? 89 3.1.1.7 additional information nonspecific inhibitor neostigmine is used to inhibit hemolysate AChE activity in order to understand the specificity of AChE for 1-naphthyl acetate or acetylthiocholine, substrate docking with AChE, BChE (EC 3.1.1.8), albumin and esterase D, acetylcholine docks with AChE, BChE, albumin and esterase D, overview Homo sapiens ? - ? 89 3.1.1.7 additional information Perforatus perforatus ChE degrades preferentially acetylthiocholine (AcSCh), and acetyl-beta-methylthiocholine (AbSCh), followed by propionylthiocholine (PrSCh), and shows only low activity with butyrylthiocholine (BuSCh) Perforatus perforatus ? - ? 89 3.1.1.7 additional information Pollicipes pollicipes ChE degrades preferentially propionylthiocholine (PrSCh), followed by acetyl-beta-methylthiocholine (AbSCh) and acetylthiocholine (AcSCh), while butyrylthiocholine (BuSCh) is not hydrolysed Pollicipes pollicipes ? - ? 89 3.1.1.7 additional information substrate specificities of AChE compared to butyrylcholinesterase (EC 3.1.1.8) and cocaine esterase (EC 3.1.1.84) Homo sapiens ? - ? 89 3.1.1.7 additional information the acetylcholinesterase (AChE) enzyme activity is detected using the 5,5'-dithio-bis(2-nitrobenzoic acid)-based colorimetric assay with measurement of the absorbance at 412 nm. 2,6-Dichloroindophenol acetate is performed as a chromogenic substrate also suitable for AChE activity examination Homo sapiens ? - ? 89 3.1.1.7 additional information the Dugesia japonica enzyme DjChE has intermediate features of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE, EC 3.1.1.8). Two candidate genes, Djche1 and Djche2, are responsible for DjChE activity Dugesia japonica ? - ? 89 3.1.1.7 additional information thiols block the enzymatic etching of gold nanorods(thiocholine on the rate of horseradish peroxidase-catalyzed AuNR etching), application to colorimetric detection of acetylcholinesterase activity and its inhibitors, overview Electrophorus electricus ? - ? 89 3.1.1.7 N-2-acetoxyethyl-N-methylpiperidinium + H2O - Todarodes pacificus ? - ? 446917 3.1.1.7 N-2-acetoxyethyl-N-methylpiperidinium + H2O - Berryteuthis magister ? - ? 446917 3.1.1.7 neuropeptides + H2O degradation Gallus gallus ? - ? 369714 3.1.1.7 neuropeptides + H2O degradation Rattus norvegicus ? - ? 369714 3.1.1.7 neuropeptides + H2O degradation Bos taurus ? - ? 369714 3.1.1.7 neuropeptides + H2O degradation Torpedo sp. ? - ? 369714 3.1.1.7 paraoxon + H2O mutant G117H, no activity with the wild-type enzyme Homo sapiens diethylphosphate + 4-nitrophenol - ? 36030 3.1.1.7 paraoxon + H2O mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme Bungarus fasciatus diethylphosphate + 4-nitrophenol - ? 36030 3.1.1.7 pentanoylthiocholine + H2O recombinant enzyme shows about 5% activity compared to acetylthiocholine Homo sapiens thiocholine + pentanoate - ? 417463 3.1.1.7 pentanoylthiocholine + H2O recombinant enzyme shows about 5% activity compared to acetylthiocholine Lucilia cuprina thiocholine + pentanoate - ? 417463 3.1.1.7 Phe + Leu - Bos taurus Gly + Gly + Gly - ? 83084 3.1.1.7 phenylacetylthiocholine + H2O recombinant enzyme shows about 3% activity compared to acetylthiocholine Lucilia cuprina thiocholine + phenylacetate - ? 417469 3.1.1.7 phenylacetylthiocholine + H2O recombinant enzyme shows about 7% activity compared to acetylthiocholine Homo sapiens thiocholine + phenylacetate - ? 417469 3.1.1.7 pivaloylthiocholine + H2O recombinant enzyme shows about 5% activity compared to acetylthiocholine Homo sapiens thiocholine + pivalate - ? 417489 3.1.1.7 pivaloylthiocholine + H2O recombinant enzyme shows less than 1% activity compared to acetylthiocholine Lucilia cuprina thiocholine + pivalate - ? 417489 3.1.1.7 propionylcholine chloride + H2O - Macroptilium atropurpureum choline chloride + propionate - ? 393348 3.1.1.7 propionylcholine iodide + H2O - Gammarus pulex choline iodide + propionate - ? 452557 3.1.1.7 propionylthiocholine + H2O - Bos taurus propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Oreochromis niloticus propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Eledone moschata propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Rhyzopertha dominica propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Bactrocera dorsalis propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Nephotettix cincticeps Uhler propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Colossoma macropomum propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Rachycentron canadum propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Arapaima gigas propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O preferred over acetylthiocholine Zea mays propanoate + thiocholine - ? 73378 3.1.1.7 propionylthiocholine + H2O - Homo sapiens thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Mytilus edulis thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Mytilus galloprovincialis thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Schizaphis graminum thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Locusta migratoria manilensis thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Palaemon serratus thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Ctenocephalides felis thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Pardosa pseudoannulata thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Aphis citricidus thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Pollicipes pollicipes thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Perforatus perforatus thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O low activity Pardosa pseudoannulata thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O good substrate Mytilus galloprovincialis thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O native and recombinant enzyme show about 70% activity compared to acetylthiocholine Lucilia cuprina thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O recombinant enzyme shows about 52% activity compared to acetylthiocholine Homo sapiens thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O 71% and 64% activity compared to acetylthiocholine with isozymes AChEA and AChEB, respectively Heterorhabditis bacteriophora thiocholine + propionate - ? 364359 3.1.1.7 propionylthiocholine + H2O - Dendrobaena veneta thiocholine + propanoate - ? 382676 3.1.1.7 propionylthiocholine chloride + H2O - Macroptilium atropurpureum thiocholine chloride + propionate - ? 393349 3.1.1.7 propionylthiocholine iodide + H2O - Schizaphis graminum thiocholine iodide + propionate - ? 393351 3.1.1.7 propionylthiocholine iodide + H2O - Gammarus pulex thiocholine iodide + propionate - ? 393351 3.1.1.7 propionylthiocholine iodide + H2O - Cyprinus carpio thiocholine iodide + propionate - ? 393351 3.1.1.7 propionylthiocholine iodide + H2O preferred substrate Eisenia andrei thiocholine iodide + propionate - ? 393351 3.1.1.7 propionylthiocholine iodide + H2O 74.6% activity compared to acetylthiocholine Heterorhabditis bacteriophora thiocholine iodide + propionate - ? 393351 3.1.1.7 propylthiocholine + H2O - Rhopalosiphum padi thiocholine + propanol - ? 430654 3.1.1.7 propylthiocholine + H2O - Sitobion avenae thiocholine + propanol - ? 430654 3.1.1.7 S-acetylthiocholine + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Drosophila melanogaster acetate + thiocholine - ? 401859 3.1.1.7 S-acetylthiocholine + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Mus musculus acetate + thiocholine - ? 401859 3.1.1.7 S-acetylthiocholine + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens acetate + thiocholine - ? 401859 3.1.1.7 S-acetylthiocholine + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Rattus norvegicus acetate + thiocholine - ? 401859 3.1.1.7 S-acetylthiocholine + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Clytia hemisphaerica acetate + thiocholine - ? 401859 3.1.1.7 S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Mus musculus acetate + thiocholine iodide - ? 401860 3.1.1.7 S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens acetate + thiocholine iodide - ? 401860 3.1.1.7 S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Rattus norvegicus acetate + thiocholine iodide - ? 401860 3.1.1.7 S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Sus scrofa acetate + thiocholine iodide - ? 401860 3.1.1.7 S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Electrophorus electricus acetate + thiocholine iodide - ? 401860 3.1.1.7 S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB, the enzyme contains a Ser, Glu, and His catalytic triad, overview Cyprinus carpio acetate + thiocholine iodide - ? 401860 3.1.1.7 S-butyrylthiocholine + H2O - Schizaphis graminum thiocholine + butyrate - ? 364396 3.1.1.7 S-butyrylthiocholine + H2O - Bactrocera dorsalis thiocholine + butyrate - ? 364396 3.1.1.7 S-butyrylthiocholine iodide + H2O - Schizaphis graminum thiocholine iodide + butyrate - ? 415949 3.1.1.7 succinyldicholine + H2O - Mus musculus 2 choline + succinate - ? 393575 3.1.1.7 [leu5] enkephalin + H2O - Bos taurus Tyr + Leu - ? 83081 3.1.1.7 [met5] enkephalins + H2O - Bos taurus Tyr + Met - ? 83082