3.1.1.7	acetylcholine + H2O	-	
3.1.1.7	acetylcholine + H2O	acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline	
3.1.1.7	acetylcholine + H2O	acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion	
3.1.1.7	acetylcholine + H2O	key enzyme in the central and peripheral nervous systems where it is responsible for the hydrolysis of neurotransmitter acetylcholine into choline and acetate	
3.1.1.7	acetylcholine + H2O	the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview	
3.1.1.7	acetylcholine + H2O	inactivation of transmitter substance operating in cholinergic neurotransmission	
3.1.1.7	acetylcholine + H2O	synaptic transmission, termination of impulse transmission at cholinergic synapses by hydrolysis	
3.1.1.7	acetylcholine chloride + H2O	-	
3.1.1.7	acetylthiocholine + H2O	-	
3.1.1.7	additional information	-	
3.1.1.7	additional information	pivotal role in the cholinergic system, rapid termination of nerve impulse transmission	
3.1.1.7	additional information	calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview	
3.1.1.7	additional information	the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues	
3.1.1.7	additional information	the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview	
3.1.1.7	additional information	acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission	
3.1.1.7	additional information	AChE is an acetylcholine-hydrolyzing enzyme and is implicated in cognitive functions and probably plays important roles in neurodegenerative disorders, including Alzheimer's disease	
3.1.1.7	additional information	brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview	
3.1.1.7	additional information	inhibition of AChE, along with the butyrylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia	
3.1.1.7	additional information	presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview	
3.1.1.7	neuropeptides + H2O	degradation