3.1.1.7 aluminium chloride activates the enzyme in vitro and in vivo after oral treatment 650742 3.1.1.7 ammonium sulfate activates optimally at 0.2 M 677887 3.1.1.7 Ca2+ activates isozymes AChEA and AChEB 750356 3.1.1.7 Ca2+ activation above 1 mM 114179 3.1.1.7 Ca2+ divalent metal ion required 114169 3.1.1.7 Co2+ activates isozymes AChEA and AChEB 750356 3.1.1.7 Iron in vitro, iron promotes a significant increase in AChE activity in brain (52%) and liver (53%) at the higher concentration (2.6 mM). In vivo, a significant increase in enzyme activity is observed in the presence of 15 mg/l in both, brain (62%) and liver tissue (70%) 729759 3.1.1.7 Mg2+ activation above 1 mM 114179 3.1.1.7 Mg2+ ameliorates inhibitory effects of AChE inhibitors 710592 3.1.1.7 Mg2+ divalent metal ion required, highest activity 114169 3.1.1.7 Mg2+ omission leads to a 20% decrease in activity 651469 3.1.1.7 Mn2+ activates isozymes AChEA and AChEB 4.9 and 6.1fold at 1 mM, respectively 750356 3.1.1.7 Mn2+ activation above 1 mM 114179 3.1.1.7 Mn2+ divalent metal ion required, effective in lowest concentration 114169 3.1.1.7 additional information AchE is not affected by Ca2+ 677953 3.1.1.7 additional information no or poor effect by Al3+, Ba2+, Mg2+, Mn2+, and Fe2+ at 1 mM 749733 3.1.1.7 additional information no or poor effects by 1 mM of Fe2+, Mn2+, Mg2+, and K+ 749734