Literature summary for 2.4.1.224 extracted from

Wang, X.; Cornelis, F.M.F.; Lories, R.J.; Monteagudo, S.
Exostosin-1 enhances canonical Wnt signaling activity during chondrogenic differentiation (2019), Osteoarthritis Cartilage, 27, 1702-1710 .

Search for more literature for 2.4.1.224

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16394	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ATDC-5 cell	-	Homo sapiens	-
chondrocyte	articular chondrocyte	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
exostosin-1	-	Homo sapiens
EXT1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	Ext1 knock-down reduces heparan sulfate, and increases chondrogenic markers and proteoglycan accumulation. Ext1 knock-down reduces active Wnt/beta-catenin signaling	Homo sapiens
physiological function	the enzyme is required for heparan sulfate chain elongation in heparan sulfate-proteoglycan biosynthesis. EXT1 affects chondrogenic differentiation of precursor cells, in part via changes in the activity of Wnt/beta-catenin signaling. Wnt/beta-catenin signaling controls Ext1 expression, suggesting a regulatory loop between EXT1 and Wnt/beta-catenin signaling during chondrogenesis	Homo sapiens

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Release 2023.1 (January 2023)