Application | Comment | Organism |
---|---|---|
drug development | COS may serve as a potential therapeutic candidate for the treatment of metastatic breast cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable overexpression of N-acetylglucosaminyltransferase V (GnT-V) in breast cancer MCF-10A cell line | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | chitosan oligosaccharides (COS) with a degree of polymerization (DP) of 2-6 inhibit breast epithelial cell migration through downregulation of GnT-V and its products, branched N-glycans. Antimetastatic potency of COS and the underlying mechanism, overview. COS may serve as a potential therapeutic candidate for the treatment of metastatic breast cancer. Glycosyltransferase-modified N-glycan structures can modulate cell migration and thereby cancer metastasis as well | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q09328 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | epithelial and metastatic | Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | branched N-glycans modified by GnT-V are evaluated by lectin blot analysis. The reactivities with Datura stramonium lectin (DSA) or leuko-agglutinating phytohemagglutinin (L4-PHA lectin), which specifically recognize, that branched N-glycans are clearly increased in the GnT-V transfectants compared to the control cells | Homo sapiens | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
GnT-V | - |
Homo sapiens |
Mgat5 | - |
Homo sapiens |
N-acetylglucosaminyltransferase V | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | chitosan oligosaccharides (COS) inhibit the protein expression of GnT-V in a dose dependent manner | down |
General Information | Comment | Organism |
---|---|---|
malfunction | GnT-V overexpression greatly promotes cell migration in the transfectants by using wound healing assay. But the induction in the cell migration is significantly suppressed by an addition of chitosan oligosaccharides (COS) | Homo sapiens |