Literature summary for 2.3.2.34 extracted from

Gong, L.; Yeh, E.
Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway (1999), J. Biol. Chem., 274, 12036-12042 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine	Homo sapiens	conjugation of NEDD8 to UBC12 requires the involvement of APP-BP1 and UBA3	[E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P61081	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine	conjugation of NEDD8 to UBC12 requires the involvement of APP-BP1 and UBA3	Homo sapiens	[E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
Ubc12	-	Homo sapiens

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Release 2023.1 (January 2023)