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Literature summary for 2.3.2.24 extracted from

  • Stewart, M.D.; Ritterhoff, T.; Klevit, R.E.; Brzovic, P.S.
    E2 enzymes more than just middle men (2016), Cell Res., 26, 423-440 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.24

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[E1 ubiquitin-activating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine Homo sapiens
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 [E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N6-monoubiquitinyl-L-lysine
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9C0C9
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme interacts with E3 ligases of types RING and RBR, and with its own N-terminus Homo sapiens ?
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-
[E1 ubiquitin-activating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine
-
 Homo sapiens [E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N6-monoubiquitinyl-L-lysine
-
 ?

Subunits

Subunits Comment Organism
More UBE2O shows the Ext-UBC-Ext domain organization Homo sapiens

Synonyms

Synonyms Comment Organism
E2-230K
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 Homo sapiens
UBE2O
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 Homo sapiens
ubiquitin-conjugating enzyme E2
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 Homo sapiens

General Information

General Information Comment Organism
evolution humans have about 40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g. SUMO and NEDD8). Common functional and structural features that define unifying themes among E2s, overview. Highly specific chain builders such as Ube2N, Ube2S, and Ube2R1 can only transfer their conjugated Ub to another Ub molecule. This leads to a division of labor among E2s in which one E2 initiates or primes chain synthesis and a second E2 builds and extends the polyUb chain Homo sapiens
metabolism ubiquitin-conjugating enzymes (E2s) are the central players in the trio of enzymes responsible for the attachment of ubiquitin (Ub) to cellular proteins. E2 regulation mechanisms, overview Homo sapiens
additional information E2 structure-function analysis, overview. Enzyme UBE2O is a large multidomain E2/E3 hybrid performing the E2 and the E3 reaction Homo sapiens
physiological function humans have about 40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g. SUMO and NEDD8). Although the majority of E2s are only twice the size of Ub, this remarkable family of enzymes performs a variety of functional roles Homo sapiens