Cloned (Comment) | Organism |
---|---|
expressed in Pichia pastoris | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
serine-borate | competitive inhibitor which is 8fold more potent in inhibiting isoform GGT1 than in inhibiting isoform GGT5; competitive inhibitor which is 8fold more potent in inhibiting isoform GGT1 than in inhibiting isoform GGT5 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
GSSG | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0099 | - |
S-Methylglutathione | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0102 | - |
leukotriene C4 | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0105 | - |
GSH | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0106 | - |
GSH | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0108 | - |
leukotriene C4 | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0131 | - |
S-(4-nitro-benzyl)glutathione | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0148 | - |
S-(4-nitro-benzyl)glutathione | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0182 | - |
S-Methylglutathione | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0334 | - |
5-L-glutamyl-L-leucine | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0346 | - |
glutathione sulfonic acid | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0426 | - |
GSSG | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
0.0751 | - |
glutathionesulfonic acid | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
22000 | - |
1 * 64000 + 1 * 22000, isoform GGT1, SDS-PAGE | Homo sapiens |
25000 | - |
1 * 64000 + 1 * 25000, isoform GGT5, SDS-PAGE | Homo sapiens |
64000 | - |
1 * 64000 + 1 * 22000, isoform GGT1, SDS-PAGE | Homo sapiens |
64000 | - |
1 * 64000 + 1 * 25000, isoform GGT5, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P19440 | isoform GGT1 | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-L-glutamyl-4-nitroanilide + glycylglycine | substrate for isoform GGT1 | Homo sapiens | 5-L-glutamyl-glycylglycine + 4-nitroaniline | - |
? | |
5-L-glutamyl-L-leucine + glycylglycine | - |
Homo sapiens | L-Leu + 5-L-glutamyl-glycylglycine | - |
? | |
glutathione sulfonic acid + glycylglycine | - |
Homo sapiens | ? | - |
? | |
glutathionesulfonic acid + glycylglycine | - |
Homo sapiens | ? | - |
? | |
GSH + glycylglycine | - |
Homo sapiens | L-Cys-Gly + 5-L-glutamyl-glycylglycine | - |
? | |
GSSG + glycylglycine | - |
Homo sapiens | L-Cys-Gly + 5-L-glutamyl-glycylglycine | - |
? | |
leukotriene C4 + glycylglycine | - |
Homo sapiens | leukotriene D4 + 5-L-glutamyl-glycylglycine | - |
? | |
additional information | isoform GGT5 does not cleave 5-L-glutamyl-4-nitroanilide and gamma-glutamyl leucine | Homo sapiens | ? | - |
? | |
S-(4-nitro-benzyl)glutathione + glycylglycine | - |
Homo sapiens | ? | - |
? | |
S-methylglutathione + glycylglycine | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 64000 + 1 * 22000, isoform GGT1, SDS-PAGE | Homo sapiens |
heterodimer | 1 * 64000 + 1 * 25000, isoform GGT5, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
gamma-glutamyl transpeptidase | - |
Homo sapiens |
GGT1 | isoform | Homo sapiens |
GGT5 | isoform | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
4.2 | - |
serine-borate | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
41.6 | - |
serine-borate | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens |