Protein Variants | Comment | Organism |
---|---|---|
additional information | the lethal mutation UU2492-3C affects the function of ribosomal peptidyl transferase center. Binding of Phe-tRNAPhe to the A site of ribosomes with mutation UU2492-3C is much lower comparing to wild type ribosomes (27% and 77%, respectively). Mutant ribosomes are not able to catalyze peptidyl transfer reaction with puromycin as the A-site substrate | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
ribosome | - |
Escherichia coli | 5840 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Phe-tRNA + puromycin | - |
Escherichia coli | tRNA + L-Phe-puromycin | - |
? | |
peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 | - |
Escherichia coli | tRNA1 + peptidyl-amino-tRNA2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptidyl transferase | - |
Escherichia coli |
PTC | peptidyl transferase center | Escherichia coli |