Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [histone H4]-L-lysin16 | Mus musculus | - |
CoA + [histone H4]-N6-acetyl-L-lysine16 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9D1P2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hematopoietic stem cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [histone H4]-L-lysin16 | - |
Mus musculus | CoA + [histone H4]-N6-acetyl-L-lysine16 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
K(lysine) acetyltransferase 8 | - |
Mus musculus |
KAT8 | - |
Mus musculus |
Mof | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | homozygous enzyme loss leads to lethal hematopoietic failure in mice at an early postnatal stage. Enzyme loss in adult mice results in dramatic hematopoietic failure | Mus musculus |
physiological function | the enzyme is a developmental-stage-specific chromatin regulator whose activity is essential for adult but not early and midgestational murine hematopoietic maintenance. Enzyme activity is required for adult hematopoietic cell survival | Mus musculus |