Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Mus musculus |
lecithin/cholesterol acyltransferase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency in LCAT sensitizes mice to diet-induced hepatic deposition of triglycerides and alterations in hepatic histology and architecture. Mechanistic analysis indicate that this is due to enhanced intestinal absorption of dietary triglycerides, accelerated clearance of postprandial triglycerides from the circulation and reduced rate of hepatic triglyceride secretion. Ectopic expression of human LCAT by gene transfer in LCAT-/- mice fed a Western-type diet for 12 weeks result in a significant reduction in their hepatic triglyceride content and a great improvement of hepatic histology and architecture | Mus musculus |