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Literature summary for 2.3.1.308 extracted from

  • Mok, J.W.; Choi, K.W.
    Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development (2021), Proc. Natl. Acad. Sci. USA, 118, e2010140118 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.308

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta(DE3) cells Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
 Drosophila melanogaster 5874
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Sepharose column chromatography and amylose Sepharose resin column chromatography Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + an N-terminal-L-methionyl-[alpha-tubulin]
-
 Drosophila melanogaster an N-terminal-Nalpha-acetyl-L-methionyl-[alpha-tubulin] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-methionyl-[beta-tubulin]
-
 Drosophila melanogaster an N-terminal-Nalpha-acetyl-L-methionyl-[beta-tubulin] + CoA
-
 ?
additional information alphabeta-tubulin dimers are not acetylated by the enzyme Drosophila melanogaster ?
-
-

Subunits

Subunits Comment Organism
? x * 55000, GST-tagged enzyme, SDS-PAGE Drosophila melanogaster

Synonyms

Synonyms Comment Organism
CG11539
-
 Drosophila melanogaster
microtubule-associated Nat9
-
 Drosophila melanogaster
Mnat9
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction enzyme loss of causes severe developmental defects in multiple tissues. Enzyme loss results in various spindle defects during mitosis in the syncytial embryo. Knockdown of enzyme causes apoptotic cell death in the wing disc Drosophila melanogaster
physiological function the enzyme regulates cell signaling and microtubule stability. The enzyme is required for regulation of c-Jun N-terminal kinase signaling to promote cell survival in developing Drosophila organs Drosophila melanogaster