Inhibitors | Comment | Organism | Structure |
---|---|---|---|
[histone H3]-difluoroacetyl-L-lysine | - |
Homo sapiens | |
[histone H3]-difluoroacetyl-L-lysine | - |
Saccharomyces cerevisiae | |
[histone H3]-monofluoroacetyl-L-lysine | - |
Homo sapiens | |
[histone H3]-monofluoroacetyl-L-lysine | - |
Saccharomyces cerevisiae | |
[histone H3]-thioacetyl-L-lysine | most potent inhibitor | Homo sapiens | |
[histone H3]-thioacetyl-L-lysine | most potent inhibitor | Saccharomyces cerevisiae | |
[histone H3]-trifluoroacetyl-L-lysine | - |
Homo sapiens | |
[histone H3]-trifluoroacetyl-L-lysine | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6-acetyl-L-lysine + NAD+ + H2O | - |
Homo sapiens | [histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[histone H3]-N6-acetyl-L-lysine + NAD+ + H2O | - |
Saccharomyces cerevisiae | [histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HST2 | - |
Saccharomyces cerevisiae |
Sir2 | - |
Homo sapiens |
Sir2 | - |
Saccharomyces cerevisiae |
SIRT1 | - |
Homo sapiens |
SIRT2 | - |
Homo sapiens |
SIRT3 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Saccharomyces cerevisiae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00102 | - |
at pH 7.5 and 25°C | Saccharomyces cerevisiae | [histone H3]-thioacetyl-L-lysine | |
0.061 | - |
at pH 7.5 and 25°C | Saccharomyces cerevisiae | [histone H3]-trifluoroacetyl-L-lysine | |
0.132 | - |
at pH 7.5 and 25°C | Saccharomyces cerevisiae | [histone H3]-difluoroacetyl-L-lysine | |
0.133 | - |
at pH 7.5 and 25°C | Saccharomyces cerevisiae | [histone H3]-monofluoroacetyl-L-lysine |