Literature summary for 2.3.1.108 extracted from

Coombes, C.; Yamamoto, A.; McClellan, M.; Reid, T.A.; Plooster, M.; Luxton, G.W.; Alper, J.; Howard, J.; Gardner, M.K.
Mechanism of microtubule lumen entry for the alpha-tubulin acetyltransferase enzyme alphaTAT1 (2016), Proc. Natl. Acad. Sci. USA, 113, E7176-E7184 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microtubule	alphaTaT1 enters the microtubule lumen through the microtubule ends, and through bends or breaks in the lattice. AlphaTat1 is concentrated near th microtubule ends	Homo sapiens	5874	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q5SQI0	-	-

Synonyms

Synonyms	Comment	Organism
alphaTAT1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	alphaTaT1 enters the microtubule lumen through the microtubule ends, and through bends or breaks in the lattice. Once alphaTat1 enters the microtubule lumen, the mobility of alphaTat1 within the lumen is controlled by its affinity for its acetylation sites, due to the rapid rebinding of alphaTat1 onto highly concentrated alpha-tubulin acetylation sites. Microtuble acetylation occurs at microtubule ends and is facilitated by new latice openings	Homo sapiens

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Release 2023.1 (January 2023)