Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [alpha-tubulin]-L-lysine | Caenorhabditis elegans | - |
CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [alpha-tubulin]-L-lysine | - |
Caenorhabditis elegans | CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-TAT | - |
Caenorhabditis elegans |
alpha-tubulin acetyltransferase | - |
Caenorhabditis elegans |
Mec-17 | - |
Caenorhabditis elegans |
tubulin acetyltransferase | - |
Caenorhabditis elegans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
malfunction | touch receptor neurons in mec-17 but not atat-2 mutants exhibit morphological defects, phenotype, overview. Both mec-17(ok2109) and mec-17(u265) produced an increase in the length of the touch receptor neuron processes, effects on touch receptor neuron microtubule organization and structure, overview. Enzymatically inactive MEC-17 mutants rescue some of the mec-17 phenotypes, the function of mec-17 is protein-dependent | Caenorhabditis elegans |
physiological function | the enzymatic activity of the alpha-tubulin acetyltransferase MEC-17 allows the production of 15-p microtubules in the touch receptor neurons microtubules, specific role for alpha-TAT in the formation of microtubules and in the production of higher order microtubules arrays. The alpha-TAT protein has functions that require acetyltransferase activity, such as the determination of protofilament number, and others that do not, e.g. presence of internal microtubule structures. Mec-17 and atat-2 are needed for touch sensitivity and MEC-12 acetylation | Caenorhabditis elegans |