Literature summary for 2.1.1.B118 extracted from

Hannich, J.T.; Entchev, E.V.; Mende, F.; Boytchev, H.; Martin, R.; Zagoriy, V.; Theumer, G.; Riezman, I.; Riezman, H.; Knolker, H.J.; Kurzchalia, T.V.
Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans (2009), Dev. Cell, 16, 833-843 .

Search for more literature for 2.1.1.B118

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	Q9TYP1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme is specific for sterol C-4 methylation, methylation is irreversible. SrmT-1 cannot produce ergosterol	Caenorhabditis elegans	?	-	-
S-adenosyl-L-methionine + cholesta-4-en-3-one	-	Caenorhabditis elegans	S-adenosyl-L-homocysteine + lophenone	-	-
S-adenosyl-L-methionine + lathosterone	i.e. lathosterone	Caenorhabditis elegans	S-adenosyl-L-homocysteine + lophenol	-	?

Synonyms

Synonyms	Comment	Organism
sterol 4-C-methyltransferase	-	Caenorhabditis elegans
sterol A-ring methylase	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
physiological function	loss of STRM-1 function leads to elevated levels of dafachronic acid and inefficient stress-resistant dauer larva formation. Methylated sterols are strongly elevated in dauer larvae, and Strm-.1 acts downstream of DAF-9 and DAf-12	Caenorhabditis elegans

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)