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Literature summary for 2.1.1.8 extracted from

  • Maw, H.H.; Zeng, X.; Campbell, S.; Taub, M.E.; Teitelbaum, A.M.
    N-Methylation of BI 187004 by thiol S-methyltransferase (2018), Drug Metab. Dispos., 46, 770-778 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
amodiaquine inhibits the reaction with BI 187004 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50135
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + BI 187004 BI 187004, i.e. an 11beta-hydroxysteroid dehydrogenase 1 inhibitor Homo sapiens S-adenosyl-L-homocysteine + 1-(1-methyl-1H-benzimidazole-6-carbonyl)-1,2,3,4,5,5a,10,10a-octahydroindeno[2,1-b]azepine-7-carbonitrile
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