Cloned (Comment) | Organism |
---|---|
- |
Cryptosporidium hominis |
Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid | Cryptosporidium hominis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid | inhibitor of Cryptosporidium hominis thymidylate synthase with 5fold selectivity over the human enzyme. Compound also has anti-cryptosporidial activity in cell culture and inhibits dihydrofolate reductase enzyme activity with IC50 values of 0.049 microM | Cryptosporidium hominis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptosporidium hominis | - |
bifunctional thymidylate synthase and dihydrofolate reductase | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00038 | - |
pH not specified in the publication, temperature not specified in the publication | Cryptosporidium hominis | 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid |